1234906-53-6Relevant academic research and scientific papers
A simple and convenient synthesis of substituted furans and pyrroles by CuCl2-catalyzed heterocyclodehydration of 3-yne-1,2-diols and N-Boc- or N-tosyl-1-amino-3-yn-2-ols
Gabriele, Bartolo,Plastina, Pierluigi,Vetere, Mabel V.,Veltri, Lucia,Mancuso, Raffaella,Salerno, Giuseppe
, p. 3565 - 3567 (2010)
A simple and economical synthesis of substituted furans and pyrroles, by ligand-free CuCl2-catalyzed heterocyclodehydration of readily available 3-yne-1,2-diols and N-Boc- or N-tosyl-1-amino-3-yn-2-ols, respectively, is presented. Reactions are carried out in MeOH at 80-100 °C for 1-24 h and afford the corresponding heterocyclic derivatives in 53-99% isolated yields.
