1235-28-5

Usage

Benzimidazole ring

A heterocyclic aromatic ring system consisting of a benzene ring fused to a five-membered ring containing two nitrogen atoms.

Diphenylmethanol group

A functional group consisting of a benzyl alcohol (a hydroxyl group attached to a benzene ring) with two phenyl groups attached to the carbon atom bearing the hydroxyl group.

White solid

A description of the physical appearance of the compound, indicating that it is a solid at room temperature and is white in color.

Molecular weight

308.36 g/mol, indicating the mass of one mole of the compound.

Potential applications in the pharmaceutical industry

The compound's structural features make it a versatile building block for the synthesis of various biologically active compounds.

Pharmacological properties

The compound has the potential to exhibit antimicrobial, antifungal, and antiviral activities.

Interesting target for further research and development

The unique structure and properties of the compound make it a promising candidate for further study in the field of medicinal chemistry.

Upstream product

• 7475-56-1 chloro(diphenyl)acetic acid 
• 95-54-5 1,2-diamino-benzene 
• 119-61-9 benzophenone 
• 19541-99-2 benzoimidazol-1-yl-methanol 
• 19213-18-4 1-pyrrolidin-1-ylmethyl-1H-benzoimidazole 
• 123117-53-3 1-(dimethylamino)benzimidazole 
• 51-17-2 benzoimidazole 

Relevant academic research and scientific papers

METALLATION OF 1-DIALKYLAMINOBENZIMIDAZOLES

In contrast to 1-amino- and 1-alkylaminobenzimidazoles, 1-di-alkylaminobenzimidazoles are metallated by n-butyl-lithium in absolute ether at the 2-position.The subsequent treatment of the lithium derivatives by electrophilic reagents, in which role benzop

A New Synthetic Method for the 2-Substitution of N-Unsubstituted Benzimidazoles: Formaldehyde as a Versatile Protecting Agent for Heterocyclic NH

N-Unsubstituted benzimidazoles 1 are readily converted in a one-pot sequence into 2-substituted derivatives 2 with good overall yields.N-Protection with formaldehyde and lithiation with lithium N,N-diisopropylamide (LDA), n-butyllithium, or tert-butyllithium gives the dilithiohemiaminals 6, which readily react with a range of electrophiles at the 2-carbon.The 2-substituted 1-(lithioxymethyl)benzimidazoles 7 undergo smooth acid-catalyzed dehydroxymethylation under mild conditions to give N-unsubstituted 2-substituted benzimidazoles 2.

Synthesis of 2-Substituted Imidazoles and Benzimidazoles and of 3-Substituted Pyrazoles by Lithiation of N-(Dialkylamino)methyl Heterocycles

The lithiation of N-(dialkylamino)methyl (aminal) derivatives of imidazole, benzimidazole, and pyrazole (themselves readily available from parent heterocycles, formaldehyde, and a secondary amine) occurs smoothly at 2-, 2-, and 5-positions, respectively, upon treatment with n-butyllithium in ether or tetrahydrofuran.Reaction with electrophiles, and subsequent facile acid-catalyzed hydrolysis of the protecting group, provides 2-substituted imidazoles, 2-substituted benzimidazoles, and 3(5)-substituted pyrazoles in good overall yields.