1H-benzimidazol-2-yl(diphenyl)methanol

Base Information

• Chemical Name: 1H-benzimidazol-2-yl(diphenyl)methanol
• CAS No.: 1235-28-5
• Molecular Formula: C20H16 N2 O
• Molecular Weight: 300.36
• Mol file: 1235-28-5.mol

Synonyms:2-Benzimidazolemethanol,a,a-diphenyl- (7CI,8CI); 2-(a-Hydroxybenzhydryl)benzimidazole; 2-(a-Phenyl-a-hydroxybenzyl)benzimidazole;NSC 78708

Chemical Property of 1H-benzimidazol-2-yl(diphenyl)methanol

Chemical Property:

• Vapor Pressure: 1.74E-14mmHg at 25°C
• Boiling Point: 584.1°Cat760mmHg
• Flash Point: 307.1°C
• Density: 1.272g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-benzimidazol-2-yl(diphenyl)methanol

There total 7 articles about 1H-benzimidazol-2-yl(diphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1-dimethylamino-2-(α-hydroxybenzhydryl)benzimidazole → 2-benzhydryl-1H-benzo[d]imidazole (5228-77-3) + 2-(α-hydroxybenzhydryl)benzimidazole (1235-28-5)

Guidance literature:

With ammonia; sodium; at -78 ℃; for 0.5h;

DOI:10.1007/BF00531477

Reference yield:

benzoimidazole (51-17-2,79351-71-6) → 2-(α-hydroxybenzhydryl)benzimidazole (1235-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.08 h / 20 °C

2: LDA / 1.) THF, -20 deg C, 55 min, 2.) from -78 deg C to 20 deg C, 8 h

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1021/jo00273a032

Reference yield:

benzophenone (119-61-9) + benzoimidazol-1-yl-methanol (19541-99-2) → 2-(α-hydroxybenzhydryl)benzimidazole (1235-28-5)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -20 deg C, 55 min, 2.) from -78 deg C to 20 deg C, 8 h;

DOI:10.1021/jo00273a032

upstream raw materials:

chloro(diphenyl)acetic acid

1,2-diamino-benzene

benzophenone

benzoimidazol-1-yl-methanol

Refernces

• 1、 Katritzky, Alan R.,Akutagawa, Kunihiko. "A New Synthetic Method for the 2-Substitution of N-Unsubstituted Benzimidazoles: Formaldehyde as a Versatile Protecting Agent for Heterocyclic NH". . p. 2949 - 2952. Retrieved 2007/10/02.