1235239-16-3Relevant academic research and scientific papers
A Central-to-Axial Chirality Conversion Strategy for the Synthesis of C-N Axially Chiral N-Arylpyrroles
Liu, Ningning,Wang, Tao,Wen, Ziwei,Zhao, Yuan,Zhong, Shiping
supporting information, p. 2842 - 2846 (2022/05/03)
We present a central-to-axial chirality conversion strategy for the construction of C-N axially chiral N-arylpyrroles via a gold(I)-catalyzed 5-endo-dig cyclization/dehydration cascade from amino acid derivatives. The reaction exhibits high efficiency on the central-to-axial chirality conversion. Density functional theory calculations suggest that the stereospecificity during the central-to-axial chirality conversion lies in the stability of the conformations of the amino alcohol and the corresponding low barrier transition state.
Highly active chiral ruthenium-based metathesis catalysts through a monosubstitution in the N-heterocyclic carbene
Tiede, Sascha,Berger, Anke,Schlesiger, David,Rost, Daniel,Luehl, Anja,Blechert, Siegfried
supporting information; experimental part, p. 3972 - 3975 (2010/09/03)
(Chemical Equotion Present) Single (substitution) is better: New chiral ruthenium metathesis (pre)catalysts with a monosubstituted carbon atom in the N-heterocyclic carbene ligand are highly stable in solution, initiate easily, show very high enantioselectivity and excellent E selectivity in asymmetric ring-opening cross-metathesis (see scheme).
