1235456-91-3Relevant academic research and scientific papers
Acetic acid aldol reactions in the presence of trimethylsilyl trifluoromethanesulfonate
Downey, C. Wade,Johnson, Miles W.,Lawrence, Daniel H.,Fleisher, Alan S.,Tracy, Kathryn J.
, p. 5351 - 5354 (2010)
(Figure presented) In the presence of TMSOTf and a trialkylamine base, acetic acid undergoes aldol addition to non-enolizable aldehydes under exceptionally mild conditions. Acidic workup yields the β-hydroxy carboxylic acid. The reaction appears to procee
