1235485-64-9

Basic information

• Product Name: (+)-(R)-6-methyl-2-(4-methylphenyl)hept-5-en-2-ol
• Synonyms: (+)-(R)-6-methyl-2-(4-methylphenyl)hept-5-en-2-ol
• CAS NO: 1235485-64-9
• Molecular Weight: 218.339
• Mol File: 1235485-64-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (+)-(R)-6-methyl-2-(4-methylphenyl)hept-5-en-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(R)-6-methyl-2-(4-methylphenyl)hept-5-en-2-ol(1235485-64-9)
• EPA Substance Registry System: (+)-(R)-6-methyl-2-(4-methylphenyl)hept-5-en-2-ol(1235485-64-9)

Safety Data

• Hazardous Substances Data: 1235485-64-9(Hazardous Substances Data)

Upstream product

• 110-93-0 6-Methyl-hept-5-en-2-on 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 1234780-57-4 (+)-(R)-1-[2-(allyloxy)-6-methylhept-5-en-2-yl]-4-methylbenzene 
• 63833-44-3 morpholino(p-tolyl)methanone 
• 99-94-5 p-Toluic acid 
• 874-60-2 4-methyl-benzoyl chloride 
• 5300-06-1 5-methyl-1-(4-methylphenyl)hex-4-en-1-one 
• 544-97-8 dimethyl zinc(II) 

Relevant articles and documents

Harnessing the Power of the Asymmetric Grignard Synthesis of Tertiary Alcohols: Ligand Development and Improved Scope Exemplified by One-Step Gossonorol Synthesis

A series of N-substituted cyclohexyldiaminophenolic ligands for the asymmetric Grignard synthesis of tertiary alcohols is reported. The 2,5-dimethylpyrrole-decorated ligand led to improved enantioselectivities and broadened the scope of the methodology. As an exemplar, we report an unprecedented highly selective one-step synthesis of gossonorol in 93% ee, also constituting the shortest formal syntheses of natural products boivinianin B and yingzhaosu C.

Enantioselective synthesis of (+)-gossonorol and related systems using organozinc reagents

The sesquiterpene (+)-gossonorol is prepared in only three synthetic steps in 60% overall yield and 82% ee from commercially available reagents. The key asymmetric step is the catalytic enantioselective addition of dimethylzinc to 5-methyl-1-(2-methylphen