63833-44-3

Usage

Uses

Used in Pharmaceutical Research:
(4-Methylphenyl)morpholin-4-ylmethanone is used as a potential therapeutic agent for the treatment of various diseases and conditions. Its pharmaceutical properties are being studied to explore its efficacy in addressing a range of health issues.
Used in Organic Synthesis:
As a building block in the synthesis of other organic compounds, (4-Methylphenyl)morpholin-4-ylmethanone plays a crucial role in creating new chemical entities with diverse applications across different industries.
Used in Catalyst Development:
(4-Methylphenyl)morpholin-4-ylmethanone is being investigated for its potential use as a catalyst in chemical reactions. Its ability to accelerate and control the rate of chemical reactions without being consumed in the process makes it a valuable component in the development of efficient and sustainable catalytic systems.

InChI:InChI=1/C12H15NO2/c1-10-2-4-11(5-3-10)12(14)13-6-8-15-9-7-13/h2-5H,6-9H2,1H3

Upstream product

• 110-91-8 morpholine 
• 15023-67-3 4-nitrophenyl 4-methylbenzoate 
• 39248-99-2 S-(4-nitrophenyl) 4-methylbenzothioate 
• 104-87-0 4-methyl-benzaldehyde 
• 201230-82-2 carbon monoxide 
• 624-31-7 4-tolyl iodide 
• 589-18-4 4-Methylbenzyl alcohol 
• 874-60-2 4-methyl-benzoyl chloride 
• 55949-65-0 4-[1-(4-methylphenyl)vinyl]morpholine 
• 122-00-9 para-methylacetophenone 
• 13939-06-5 molybdenum hexacarbonyl 
• 10024-89-2 morpholin hydrochloride 
• 36106-76-0 2,4-dinitrophenyl 4-methylbenzoate 
• 127029-79-2 2-morpholinyl-2-phenyl-1-(4-methylphenyl)-1-ethanone 

Downstream Products

• 55895-62-0 2-(4-methylbenzoyl)pyrrole 
• 154047-02-6 (1-Allyl-1H-pyrrole-2-yl) (4-methylphenyl)methanone 
• 154047-21-9 (1-Allyl-1H-pyrrol-2-yl)-p-tolyl-methanol 
• 1032713-75-9 3,3'-diethyl-4,4'-dimethyl-5',5-di-4-methylbenzoyl-2,2'-bipyrrole 
• 13707-23-8 N-(4-methylbenzoyl)piperidine 
• 18494-67-2 1-(morpholin-4-yl)heptan-1-one 
• 57409-40-2 4-methyl-N-benzyl-N-methylbenzamide 
• 1235485-64-9 (+)-(R)-6-methyl-2-(4-methylphenyl)hept-5-en-2-ol 
• 1235485-63-8 (-)-(S)-6-methyl-2-(4-methylphenyl)hept-5-en-2-ol 
• 1383540-97-3 (R)-7-methyl-3-(4-methylphenyl)loct-6-en-3-ol 
• 1383540-94-0 (S)-5-methyl-1-(4-methylphenyl)-1-phenylhex-4-en-1-ol 
• 1383540-95-1 (R)-7-methyl-3-(4-methylphenyl)-1-phenyl-oct-6-en-1-yn-3-ol 

Relevant academic research and scientific papers

Amide Bond Formation via the Rearrangement of Nitrile Imines Derived from N-2-Nitrophenyl Hydrazonyl Bromides

We report how the rearrangement of highly reactive nitrile imines derived from N-2-nitrophenyl hydrazonyl bromides can be harnessed for the facile construction of amide bonds. This amidation reaction was found to be widely applicable to the synthesis of primary, secondary, and tertiary amides and was used as the key step in the synthesis of the lipid-lowering agent bezafibrate. The orthogonality and functional group tolerance of this approach was exemplified by the N-acylation of unprotected amino acids.

Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow

Phosphine-mediated deoxygenative nucleophilic substitutions, such as the Mitsunobu reaction, are of great importance in organic synthesis. However, the conventional protocols require stoichiometric oxidants to trigger the formation of the oxyphosphonium i

Solar and visible-light active nano Ni/g-C3N4photocatalyst for carbon monoxide (CO) and ligand-free carbonylation reactions

In this study, we investigate the amino and alkoxycarbonylation reaction between various substituted aryl halides, benzyl iodides, and iodocyclohexane with different types of amines and alcohols in the absence of carbon monoxide gas and ligands. Similar reactions are carried out at high temperatures, in the presence of appropriate ligands, stoichiometric amounts of bases, and gaseous carbon monoxide, which endanger the health of organic chemists. We present a novel method that does not utilize ligands, bases, gaseous CO, and special conditions. This procedure is a redox reaction carried out by new economic nano Ni/g-C3N4at room temperature and under visible light. Mo(CO)6was used toin situgenerate CO, to resolve the problems caused by the use of CO gas. This protocol has the ability to be used on a gram scale by using a continuous flow reactor.

Extended Multicomponent Reactions with Indole Aldehydes: Access to Unprecedented Polyheterocyclic Scaffolds, Ligands of the Aryl Hydrocarbon Receptor

The participation of reactants undergoing a polarity inversion along a multicomponent reaction allows the continuation of the transformation with productive domino processes. Thus, indole aldehydes in Groebke–Blackburn–Bienaymé reactions lead to an initial adduct which spontaneously triggers a series of events leading to the discovery of novel reaction pathways together with direct access to a variety of linked, fused, and bridged polyheterocyclic scaffolds. Indole 3- and 4-carbaldehydes with suitable isocyanides and aminoazines afford fused adducts through oxidative Pictet–Spengler processes, whereas indole 2-carbaldehyde yields linked indolocarbazoles under mild conditions, and a bridged macrocycle at high temperature. These novel structures are potent activators of the human aryl hydrocarbon receptor signaling pathway.

Direct Amidation of Esters by Ball Milling**

The direct mechanochemical amidation of esters by ball milling is described. The operationally simple procedure requires an ester, an amine, and substoichiometric KOtBu and was used to prepare a large and diverse library of 78 amide structures with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochemical protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent.

Diverse functionalization of aryl halides mediated by bis(phenylsulfonyl)methane

A palladium-catalyzed coupling reaction of bis(phenylsulfonyl)methane and aryl halides was developed. A variety of bis(phenylsulfonyl)methyl arenes were prepared in good yields. The transformations of bis(phenylsulfonyl)methyl to methyl, trideuteriomethyl, ethyl, carboxyl, and other functional groups were demonstrated. The results provided a new approach to diverse functionalization of aryl halides.

Visible light-mediated synthesis of amides from carboxylic acids and amine-boranes

Here, a photocatalytic deoxygenative amidation protocol using readily available amine-boranes and carboxylic acids is described. This approach features mild conditions, moderate-to-good yields, easy scale-up, and up to 62 examples of functionalized amides with diverse substituents. The synthetic robustness of this method was also demonstrated by its application in the late-stage functionalization of several pharmaceutical molecules.

Method for preparing amide from carboxylic acid under irradiation of blue light by taking iridium and cobalt complexes as catalysts

The invention relates to a method for preparing amide from carboxylic acid under the irradiation of blue light by taking iridium and cobalt complexes as catalysts, and belongs to the field of chemistry. The method comprises the following step of: by taking R substituted carboxylic acid and R1' and R2' substituted amines as raw materials, triphenylphosphine as a deoxidizing agent, [Ir(dF(CF3)ppy)2(dtbbpy)]PF6 as a photocatalyst and Co(dmgH)(dmgH2)Cl2 as a metal complex catalyst, reacting in dichloromethane in an inert atmosphere and under the irradiation of blue light to obtain an amide compound, wherein R is an aryl group, a heteroaryl group, a protected amino group, a substituted alkyl group, a substituted aryl group or a substituted protected amino group, R1' is a hydrogen group, a substituted alkyl group, a phenyl group or a substituted phenyl group, and R2' is a hydrogen group, a substituted alkyl group, a phenyl group or a substituted phenyl group.

NaI-mediated oxidative amidation of benzyl alcohols/aromatic aldehydes to benzamides via electrochemical reaction

In this research, we have developed a mild electrochemical process for oxidative amidation of benzyl alcohols/aromatic aldehydes with cyclic amines into the corresponding benzamides. This electroorganic synthetic method proceeds using NaI as a redox mediator under ambient temperature in undivided cell, providing more than 25 examples of amide products in moderate to good yields. The benefits of this reaction include one-pot synthesis, open air condition, proceed in aqueous media and no requirement of external conducting salt, base and oxidant.