1235489-53-8Relevant articles and documents
Synthesis of Benzothiophene-Containing 10- and 11-Membered Cyclic Phostones
Matralis, Alexios N.,Tsantrizos, Youla S.
, p. 3728 - 3736 (2016/08/16)
Phosphinate and phosphonate derivatives can serve as useful transition-state analogues of proteases, as substrate mimics of DNA/RNA-processing enzymes, and as inhibitors of enzymes catalyzing the biosynthesis of isoprenoids. Synthetic methodologies for the preparation of medium-sized ring phosphonate-containing compounds (also known as phostones are currently limited to a few examples. A synthetic protocol was developed that is amenable to the parallel synthesis of structurally diverse phostones containing a benzo[b]thiophene core, which enables the profiling of such novel compounds in biological screens of potential therapeutic targets.
