C₁₀H₁₂ClO₂P

Base Information

• Chemical Name: C₁₀H₁₂ClO₂P
• CAS No.: 1235489-53-8
• Molecular Formula: C₁₀H₁₂ClO₂P
• Molecular Weight: 230.631
• Mol file: 1235489-53-8.mol

Synonyms:C₁₀H₁₂ClO₂P

Chemical Property of C₁₀H₁₂ClO₂P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₁₂ClO₂P

There total 3 articles about C₁₀H₁₂ClO₂P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl hydrogen allylphosphonate → C10H12ClO2P (1235489-53-8)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201600333

Reference yield:

dibenzyl allylphosphonate (28995-21-3) → C10H12ClO2P (1235489-53-8)

Guidance literature:

With oxalyl dichloride; In dichloromethane;

DOI:10.1039/c000622j

Reference yield:

Dibenzyl phosphite (17176-77-1) → C10H12ClO2P (1235489-53-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 1 h / -78 °C

1.2: 5 h / -78 - 20 °C

2.1: lithium bromide / acetonitrile / 18 h / Inert atmosphere; Reflux

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C / Inert atmosphere

With n-butyllithium; oxalyl dichloride; N,N-dimethyl-formamide; lithium bromide; In diethyl ether; hexane; dichloromethane; acetonitrile;

DOI:10.1002/ejoc.201600333

upstream raw materials:

dibenzyl allylphosphonate

Dibenzyl phosphite

Downstream raw materials:

C₂₆H₄₃O₆P

C₂₁H₂₄N₃O₅P

C₂₉H₄₉O₆P

C₂₁H₂₆NO₅P

Refernces

• 1、 Shih, Hao-Wei,Chen, Kuo-Ting,Chen, Shao-Kang,Huang, Chia-Ying,Cheng, Ting-Jen R,Ma, Che,Wong, Chi-Huey,Cheng, Wei-Chieh. "Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors". scheme or table. p. 2586 - 2593. Retrieved 2010/08/07.