28995-21-3Relevant academic research and scientific papers
Synthesis of the antimalarial drug FR900098 utilizing the nitroso-ene reaction
Fokin, Andrey A.,Yurchenko, Alexander G.,Rodionov, Vladimir N.,Gunchenko, Pavel A.,Yurchenko, Raisa I.,Reichenberg, Armin,Wiesner, Jochen,Hintz, Martin,Jomaa, Hassan,Schreiner, Peter R.
, p. 4379 - 4382 (2007)
The antimalarial drug FR900098 was prepared from diethyl allylphosphonate involving the nitroso-ene reaction with nitrosocarbonyl methane as the key step followed by hydrogenation and dealkylation. The utilization of dibenzyl allylphosphonate as the start
Synthesis of Benzothiophene-Containing 10- and 11-Membered Cyclic Phostones
Matralis, Alexios N.,Tsantrizos, Youla S.
, p. 3728 - 3736 (2016/08/16)
Phosphinate and phosphonate derivatives can serve as useful transition-state analogues of proteases, as substrate mimics of DNA/RNA-processing enzymes, and as inhibitors of enzymes catalyzing the biosynthesis of isoprenoids. Synthetic methodologies for the preparation of medium-sized ring phosphonate-containing compounds (also known as phostones are currently limited to a few examples. A synthetic protocol was developed that is amenable to the parallel synthesis of structurally diverse phostones containing a benzo[b]thiophene core, which enables the profiling of such novel compounds in biological screens of potential therapeutic targets.
