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Relevant academic research and scientific papers

Multicomponent click reactions catalysed by copper(I) oxide nanoparticles (Cu2ONPs) derived using Oryza sativa

Abstract: A procedure for the expedient synthesis of well-characterized Cu(I) oxide nanoparticles (Cu2ONPs) from Cu(II) salts by employing Rice (Oryza sativa) as a cheap and ready source of reducing as well as stabilizing agent has been demonstrated. The judicious choice of rice as a catalyst has helped in the symbiotic combination of two events: viz., acidic hydrolysis of starch to form glucose and the subsequent formal reduction of Cu2+ by the in-situ generated monosaccharide reducing sugar (glucose) under the alkaline condition to produce Cu2O. Further, rice was also found to be effectively stabilizing the nanoparticles from agglomeration. Optical and microscopic techniques were suitably employed for the characterization of the nanoparticles of approximately 10 nm size. Furthermore, the specifically generated nanoparticles were found to be active catalysts in an aqueous medium for Azide-alkyne Huisgen cycloaddition (Click reaction) under base free condition via one-pot multi-component addition for the synthesis of mono-, bis- and tris-1,2,3-triazoles in good to excellent yields. Graphic abstract: Cu2ONPs synthesized using hydrolysed Rice, an active catalyst for synthesis of mono-, bis- and tris-1,4-disubstituted 1,2,3-triazoles via one pot multicomponent reactions in water.[Figure not available: see fulltext.].

Copper(I)-chitin biopolymer based: An efficient and recyclable catalyst for click azide–alkyne cycloaddition reactions in water

The naturally occurring α-chitin biopolymer was employed for the immobilisation of copper(I) ion, resulting into a new bioconjugate complex, namely, Cu(I)-α-chitin (CuI-CHT) with catalytic efficiency in copper-catalysed azide–alkyne cycloaddition reaction

Cu(ii)-alginate-based superporous hydrogel catalyst for click chemistry azide-alkyne cycloaddition type reactions in water

A novel sustainable hydrogel catalyst based on the reaction of sodium alginate naturally extracted from brown algaeLaminaria digitataresidue with copper(ii) was prepared as spherical beads, namely Cu(ii)-alginate hydrogel (Cu(ii)-AHG). The morphology and

A reusable polymer-supported copper(I) catalyst for triazole click reaction on water: An experimental and computational study

In the search for establishing a clickable copper-catalysed (3?+?2) Huisgen azide–alkyne cycloaddition (CuAAC) reaction under strict conditions, in particular in terms of preventing the presence of copper particles/traces in reaction products and using an environmentally benign medium such as water, we describe here the synthesis of an aminomethyl polystyrene-supported copper(I) catalyst (Cu(I)-AMPS) and its characterization by means of Fourier transform infrared and energy-dispersive X-ray spectroscopies and scanning electron microscopy. Cu(I)-AMPS was found to be highly active in the CuAAC reaction of various organic azides with alkynes affording the corresponding 1,4-disubstituted 1,2,3-triazoles in a regioselective manner in air at room temperature and using water as solvent. The insolubility and/or partial solubility of the organic azide and alkyne precursors as well as the heterogeneous Cu(I)-AMPS catalytic system points to the occurrence of the cycloaddition at the organic–water interface ‘on water’ affording quantitative yields of water-insoluble 1,2,3-triazoles. A mechanistic study was performed using density functional theory aiming at explaining the observed reactivity and selectivity of the Cu (I)-AMPS catalyst in CuAAC reactions.

Copper(II)-dipicolinate-mediated clickable azide–alkyne cycloaddition in water as solvent

Copper(II)-dipicolinate complex [CuII(dipic)(H2O)2] (1) (H2L?=?dipicolinic acid (H2dipic)) was synthesized via oxidation of copper(I) iodide and pyridine-2,6-dicarboxylic acid in water and acetonitril

Hybrid NS ligands supported Cu(i)/(ii) complexes for azide-alkyne cycloaddition reactions

Three copper complexes of nitrogen-sulfur donor ligands, [CuBr 2(L1)] (1), [CuCl2(L2)2] (2) and [Cu 2I2(L3)]n (3) (L1 = bis(2- cyclohexylsulfanylethyl)amine, L2 = 2-(benzylsulfanylmethyl)pyridine and L3 = 2-(4-pyridylsulfanylmethyl)pyridine), have been synthesized and characterized by single-crystal X-ray diffraction (XRD), powder XRD and TGA analysis. Complexes 1 and 2 are mononuclear Cu(ii) complexes and are EPR active with distorted square-pyramidal and octahedral geometry, respectively. Complex 3 is a two-dimensional tetrahedral Cu(i) coordination polymer with 16- and 20-membered metallocycles. These complexes show good catalytic activities for one-pot azide-alkyne cycloaddition reactions in CH3OH-H2O.

Synthesis of click-chelator via Cu(I)-catalyzed alkyne-azide cycloaddition

The click-ligands based on 1,2,3-triazole and pyridine unit has been synthesized via Cu(I)-catalyzed alkyne-azide cycloaddition from corresponding organic azides and terminal alkynes. The ligand structure was characterized by NMR, IR and elemental analysis as well as single crystal diffractions. The single crystal structure of the complexes from two different ligands coordinating to Cu(II) and Co(II) ions indicated that the N(2) atom in 1,2,3-triazole unit can act as an efficient donor to metals through the rational molecular design. Copyright

Polymer-supported 1,5,7-triazabicyclo [4.4.0] dec-5-ene as polyvalent ligands in the copper-catalyzed Huisgen 1,3-dipolar cycloaddition

Abstract: New supported catalysts for the Huisgen's [3.+ 2]azide-alkyne cycloaddition have been prepared by immobilization of copper species on commercially available polymeric matrixes incorporating the 1,5,7- triazabicyclo[4.4.0]dec-5-ene (TBD) template