1235560-83-4Relevant academic research and scientific papers
Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639
Zhang, Qingwei,Xia, Zhiren,Joshi, Shailen,Scott, Victoria E.,Jarvis, Michael F.
supporting information, p. 641 - 644 (2015/06/30)
The discovery of a novel peripherally acting and selective Cav3.2 T-type calcium channel blocker, ABT-639, is described. HTS hits 1 and 2, which have poor metabolic stability, were optimized to obtain 4, which has improved stability and oral bi
NOVEL BENZENESULFONAMIDES AS CALCIUM CHANNEL BLOCKERS
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Page/Page column 79, (2010/08/08)
The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
