123557-03-9Relevant articles and documents
Aziridine-2-carboxylic acid derivatives and its open-ring isomers as a novel PDIA1 inhibitors
Leite, Irena,Andrianov, Victor,Zelencova-Gopejenko, Diana,Loza, Einars,Kazhoka-Lapsa, Iveta,Domracheva, Ilona,Stoyak, Marta,Chlopicki, Stefan,Kalvins, Ivars
, p. 1086 - 1106 (2022/01/12)
[Figure not available: see fulltext.] Acyl derivatives of aziridine-2-carboxylic acid have been synthesized and tested as PDIA1 inhibitors. Calculations of charge value and distribution in aziridine ring system and some alkylating agents were performed. For the first time was found that acyl derivatives of aziridine-2-carboxylic acid are weak to moderately active PDIA1 inhibitors.
CHIROPTICAL PROPERTIES OF THE NONPLANAR AMIDE CHROMOPHORE IN N-ACYLAZIRIDINES
Shustov, G. V.,Polyak, F. D.,Kadorkina, G. K.,Vosekalna, I. A.,Shokhen, M. A.,et al.
, p. 32 - 39 (2007/10/02)
The optically active 1-acyl-substituted (1R,2R)-2-methyl- and (1R,2S)-2-methoxycarbonylaziridines were synthesized.The nonplanarity of the amide chromophore in them and its high conformational mobility, which was caused by the rotation around the N-C(O) bond, were shown on the basis of the investigation of the CD spectra and the calculations of simple models by the MNDO method.The possible correlation of the sign of the Cotton effect of the long-wave p-?* transition with the intrinsic chirality of the chromophore was studied.
