1235588-97-2

Upstream product

• 1044518-92-4 (3R,5S)-tert-butyl 6-(tert-butyldimethylsilyloxy)-3,5-dihydroxyhexanoate 
• 124655-09-0 1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate 
• 1044518-72-0 tert-butyl 2-((4R,6S)-6-[(tert-butyl)dimethylsilyloxymethyl]-2,2-dimethyl-1,3-dioxan-4-yl)acetate 
• 131666-49-4 (2S,4R)-6-tert-butoxy-2,4-dihydroxy-6-oxohexyl benzoate 
• 131666-50-7 ((4S,6R)-6-(2-tert-butoxy-2-oxoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)methyl benzoate 
• 154026-95-6 (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester 
• 1235588-94-9 tert-butyl 2-((4R,6S)-6-(hydroxymethyl)-2-phenyl-1,3-dioxan-4-yl)acetate 
• 1235588-93-8 tert-butyl 2-((4R,6S)-6-((tert-butyldiphenylsilyloxy)methyl)-2-phenyl-1,3-dioxan-4-yl)acetate 
• 124655-07-8 (3R,5S)-tert-butyl 6-(tert-butyldiphenylsilyloxy)-3,5-dihydroxyhexanoate 
• 1235588-96-1 (((4S,6R)-6-(2-(tert-butoxy)-2-oxoethyl)-2-phenyl-1,3-dioxan-4-yl)methyl)triphenylphosphonium iodide 
• 147118-37-4 N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide 

Downstream Products

• 355806-00-7 rosuvastatin tert-butyl ester 

Relevant academic research and scientific papers

New Statin intermediate, the preparation of the same and the preparation of Rosuvastatin using the same

The present invention provides a novel producing method for producing a core intermediate (chemical formula IV) of rosuvastatin, a novel intermediate used therefor and a producing method of rosuvastatin hemi-calcium salts using the same. The novel intermediate of the present invention can be prepared with high purity and in high yields in mild conditions, and thus the rosuvastatin intermediate and rosuvastatin hemi-calcium salts can be conveniently and efficiently mass-produced without complicated processes.

PROCESS FOR THE PREPARATION OF ROSUVASTATIN

The invention relates to a process for the preparation of a HMG - CoA reductase inhibitor such as rosuvastatin, as well as intermediates useful in such process. The invention also relates to salts of HMG-CoA reductase inhibitors and processes for preparing same as well as processes for preparing pharmaceutically acceptable salts of HMG-CoA reductase inhibitors.