154026-95-6Relevant articles and documents
Rosuvastatin calcium intermediate, preparation method thereof and application of intermediate
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, (2019/04/17)
The invention discloses a rosuvastatin calcium intermediate, a preparation method thereof and an application of the intermediate. The synthesis process of the intermediate is environmentally friendly,simple and convenient to operate and low in EHS (environment health safety) risk, raw materials are easily available, and used chemical reagents are low in toxicity and low in price, so that the synthesis process of the intermediate is a green synthesis process suitable for industrial production. In addition, the intermediate is applied to synthesis of rosuvastatin calcium and key intermediates thereof, has short route and high yield, effectively reduces the industrial production cost of rosuvastatin calcium, and has a higher industrial application prospect.
Method for preparing 3,5-di-substituted hydroxyl-6-substituted capronate derivative
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Paragraph 0054; 0055; 0056; 0057; 0058; 0059; 0060; 0061, (2016/10/10)
The invention discloses a method for preparing a 3,5-di-substituted hydroxyl-6-substituted capronate derivative shown as a general formula I. The method comprises a step that carboxylate shown in a general formula II and RM are subjected to a reaction under effect of a cuprous salt catalyst. The method has the advantages that the process is simple, cost is low, a catalyst with expensive price can be avoided, generation of a by-product is reduced, the post-treatment is simple, operation is easy, reaction yield is greatly increased, and the method is more suitable for large-scale industrial production.
New Statin intermediate, the preparation of the same and the preparation of Rosuvastatin using the same
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Paragraph 0161; 0162-0165, (2017/04/20)
The present invention provides a novel producing method for producing a core intermediate (chemical formula IV) of rosuvastatin, a novel intermediate used therefor and a producing method of rosuvastatin hemi-calcium salts using the same. The novel intermediate of the present invention can be prepared with high purity and in high yields in mild conditions, and thus the rosuvastatin intermediate and rosuvastatin hemi-calcium salts can be conveniently and efficiently mass-produced without complicated processes.