123595-49-3

Upstream product

• 116021-13-7 (2S)-2-methyl-3-(trityloxy)propionic acid methyl ester 
• 76-83-5 trityl chloride 
• 105857-69-0 (2R)-2-methyl-3-(trityloxy)propan-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 352209-63-3 (2R,4S,5R)-4-((1R,3R)-1,3-Dimethyl-4-trityloxy-butyl)-5-methyl-2-phenyl-[1,3]dioxane 
• 352209-69-9 (2R,3S,4R,6R)-3-Benzyloxy-2,4,6-trimethyl-7-trityloxy-heptan-1-ol 
• 352209-64-4 Trifluoro-methanesulfonic acid (2R,3S,4R,6R)-3-benzyloxy-2,4,6-trimethyl-7-trityloxy-heptyl ester 
• 1026015-66-6 (2S,3S,4R,6R,7S,8R,10R)-3,7-Bis-benzyloxy-2,4,6,8,10-pentamethyl-11-trityloxy-undecanal 
• 352209-66-6 (2R,4S,5R)-4-((1R,3R,4S,5R,7R)-4-Benzyloxy-1,3,5,7-tetramethyl-8-trityloxy-octyl)-5-methyl-2-phenyl-[1,3]dioxane 
• 352209-67-7 (2R,3S,4R,6R,7S,8R,10R)-3,7-Bis-benzyloxy-2,4,6,8,10-pentamethyl-11-trityloxy-undecan-1-ol 
• 352209-65-5 (2R,4R,5R)-4-((3R,4S,5R,7R)-4-Benzyloxy-3,5,7-trimethyl-1-methylene-8-trityloxy-octyl)-5-methyl-2-phenyl-[1,3]dioxane 
• 352209-68-8 (3S,4R,5S,6R,8R,9S,10R,12R)-5,9-Bis-benzyloxy-4,6,8,10,12-pentamethyl-13-trityloxy-tridecan-3-ol 
• 1366246-12-9 1-methoxy-4-({[(5R)-5-methyl-6-(triphenylmethoxy)hexyl]oxy}methyl)benzene 
• 123595-51-7 (R)-4-Methyl-5-trityloxy-pentan-1-ol 
• 352209-62-2 (2R,4R,5R)-5-Methyl-4-((R)-3-methyl-1-methylene-4-trityloxy-butyl)-2-phenyl-[1,3]dioxane 
• 123595-50-6 C₂₆H₂₈O 

Relevant academic research and scientific papers

Screening of a virtual mirror-image library of natural products

We established a facile access to an unexplored mirror-image library of chiral natural product derivatives using d-protein technology. In this process, two chemical syntheses of mirror-image substances including a target protein and hit compound(s) allow the lead discovery from a virtual mirror-image library without the synthesis of numerous mirror-image compounds.

Biomimetic total synthesis of cruentaren A via aromatization of diketodioxinones

The total synthesis of cruentaren A, a biologically active resorcylate natural product, is reported. The aromatic unit was constructed via late-stage cyclization and aromatization from a diketodioxinone intermediate and macrocyclization using Fuerstner ring-closing alkyne metathesis.

Synthesis of the C15-C27 portion of venturicidins: A formal total synthesis of venturicidin X

The C15-C27 portion of venturicidin X was prepared using substitution reactions of alkyl trifluoromethanesulfonates with a vinylmetal compound followed by homogeneous hydrogenation. Together with our previous synthesis of the C1-C14 portion of venturicidin X, a formal total synthesis of venturicidin X was completed.

Heteroatom-Assisted Substitution of Acyclic Secondary Tosylates with Lithium Dialkylcuprates: An Expedient Route to Stereochemically Defined Deoxypropionate and Related Biosynthetic Subunits

Secondary tosylates of a number of acyclic molecules can be easily displaced with diorganocuprates with complete inversion of configuration.The displacement reaction is greatly facilitated when a hetero atom (S or O) is proximal to the nucleofugal group a