1236006-72-6

Basic information

• Product Name: C₂₇H₃₂BrN₃O₅
• Synonyms: C₂₇H₃₂BrN₃O₅
• CAS NO: 1236006-72-6
• Molecular Weight: 558.472
• Mol File: 1236006-72-6.mol

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₂BrN₃O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₂BrN₃O₅(1236006-72-6)
• EPA Substance Registry System: C₂₇H₃₂BrN₃O₅(1236006-72-6)

Safety Data

• Hazardous Substances Data: 1236006-72-6(Hazardous Substances Data)

Upstream product

• 1201518-42-4 C₂₁H₂₈N₂O₆ 
• 591-19-5 m-Bromoaniline 
• 1201518-34-4 (R)-2-[(4-methobenzyloxyformylamino)methyl]hexanoic acid 
• 1201518-32-2 (R)-2-((4-methoxybenzyloxyamino)methyl)hexanoic acid 
• 1201518-30-0 (S)-3-((R)-2-((4-methoxybenzyloxyamino)methyl)hexanoyl)-4-benzyloxazolidin-2-one 
• 478912-40-2 (4S)-3-(2-methylene-1-oxohexyl)-4-(phenylmethyl)-2-oxazolidinone 
• 4380-88-5 2-butylacrylic acid 
• 534-59-8 n-butylmalonic acid 
• 133-08-4 diethyl butylmalonate 
• 1201518-40-2 C₂₂H₃₀N₂O₆ 

Downstream Products

• 1236007-04-7 (S)-1-((R)-2-((formylhydroxyamino)methyl)hexanoyl)-N-(3-bromophenyl)-2,5-dihydro-1H-pyrrole-2-carboxamide 

Relevant articles and documents

Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria

Peptide deformylase (PDF) has been identified as a promising target for novel antibacterial agents. In this study, a series of novel formyl hydroxyamino derivatives were designed and synthesized as PDF inhibitors and their antibacterial activities were evaluated. Among the potent PDF inhibitors (1o, 1q, 1o′, 1q′, and 1x), in vivo studies showed that compound 1q possesses mild toxicity, a good pharmacokinetic profile and protective effects. The good in vivo efficacy and low toxicity suggest that this class of compounds has potential for development and use in future antibacterial drugs.

Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors

The synthesis and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives are reported. The antibacterial activities of these derivatives were evaluated, and some of these derivatives showed better in vitro antibacterial activity than existing drugs, including penicillin, ciprofloxacin, vancomycin, and linezolid.