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2-((2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)(pyridin-2-ylmethyl)amino)acetonitrile is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1236156-75-4

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1236156-75-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1236156-75-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,6,1,5 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1236156-75:
(9*1)+(8*2)+(7*3)+(6*6)+(5*1)+(4*5)+(3*6)+(2*7)+(1*5)=144
144 % 10 = 4
So 1236156-75-4 is a valid CAS Registry Number.

1236156-75-4Downstream Products

1236156-75-4Relevant academic research and scientific papers

Synthesis and biological evaluation of novel triazole derivatives as antifungal agents

Tang, Hui,Zheng, Can-Hui,Ren, Xiao-Hui,Liu, Jia,Liu, Na,Lv, Jia-Guo,Zhu, Ju,Zhou, You-Jun

supporting information, p. 219 - 222 (2013/06/27)

A series of 1-(benzylamino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1- yl)propan-2-ols compounds were synthesized and evaluated for their antifungal activities in vitro. The results showed that compounds 6A and 6B exhibited good antifungal activity. Compound 6A8 showed the strongest antifungal activity, which was significantly higher than that of the lead compounds and positive-control drugs Fluconazole and Itraconazole. In particular, the antifungal activity of compound 6A8 against Candida albicans and Candida krusei (MIC80 both at 0.00097 μg/mL) was 515 and 64 times that of Fluconazole, respectively. The structure-activity relationships of the synthesized compounds were discussed, and the docking model of the target compounds with fungal lanosterol 14α-demethylase (CYP51) was analyzed.

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