1236162-22-3 Usage
Uses
Used in Pharmaceutical Industry:
7-Chloro-5-hydroxyquinoline is used as a key intermediate in the synthesis of various pharmaceuticals for its antibacterial and antifungal properties. It contributes to the development of drugs that target a wide range of infections and diseases.
Used in Agrochemical Industry:
In the agrochemical industry, 7-chloro-5-hydroxyquinoline is employed as a building block in the synthesis of compounds with pesticidal and fungicidal properties. Its incorporation helps in creating agricultural products that protect crops from various pathogens and pests, ensuring higher yields and better crop quality.
Used in Analytical Chemistry:
7-Chloro-5-hydroxyquinoline is used as a chelating agent in analytical chemistry for the determination of metal ions. Its ability to form stable complexes with metal ions makes it a valuable tool in the analysis and quantification of metal concentrations in various samples.
Used in Fine Chemicals Synthesis:
7-CHLORO-5-HYDROXYQUINOLINE is also used as an intermediate in the synthesis of various fine chemicals, including dyes, pigments, and other specialty chemicals. Its versatile reactivity and functional groups make it suitable for the production of a wide range of high-value compounds used in different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1236162-22-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,6,1,6 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1236162-22:
(9*1)+(8*2)+(7*3)+(6*6)+(5*1)+(4*6)+(3*2)+(2*2)+(1*2)=123
123 % 10 = 3
So 1236162-22-3 is a valid CAS Registry Number.
1236162-22-3Relevant academic research and scientific papers
NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS
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Page/Page column 234; 235, (2017/03/14)
The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
Synthesis of 5-hydroxyquinolines
Li, Jianke,Kung, Daniel W.,Griffith, David A.
body text, p. 3876 - 3878 (2010/08/19)
A series of 5-hydroxyquinolines has been prepared via the Skraup reaction. Several regioisomers were made either by selective displacement of a leaving group or by using a bromo substituent as a blocking group. The bromo group was found to be an excellent blocking group due to its stability during the Skraup reaction and easy removal thereafter. Halides at the 5-position of quinoline were found to be much more reactive than those at the 7- and 8-positions. Finally, we have also found a unique method to reduce the pyridyl ring on quinolines, leaving a halogen substituent untouched.
