123652-87-9

Basic information

• Product Name: probestin
• Synonyms: probestin;N-[(2S,3R)-4-Phenyl-2-hydroxy-3-aminobutyryl]-L-Leu-L-Pro-L-Pro-OH
• CAS NO: 123652-87-9
• Molecular Formula: C26H38N4O6
• Molecular Weight: 502.608
• Mol File: 123652-87-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 841.3°Cat760mmHg
• Flash Point: 462.6°C
• Appearance: /
• Density: 1.283g/cm³
• Vapor Pressure: 4.72E-30mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: probestin(CAS DataBase Reference)
• NIST Chemistry Reference: probestin(123652-87-9)
• EPA Substance Registry System: probestin(123652-87-9)

Safety Data

• Hazardous Substances Data: 123652-87-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C26H38N4O6/c1-16(2)14-19(28-23(32)22(31)18(27)15-17-8-4-3-5-9-17)24(33)29-12-6-10-20(29)25(34)30-13-7-11-21(30)26(35)36/h3-5,8-9,16,18-22,31H,6-7,10-15,27H2,1-2H3,(H,28,32)(H,35,36)/t18-,19+,20+,21+,22+/m1/s1

Upstream product

• 612096-25-0 (S)-1-{(S)-1-[(S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carbonyl}-pyrrolidine-2-carboxylic acid 
• 62023-65-8 (2S,3R)-3-[(tert-butoxycarbonyl) amino]-2-hydroxy-4-phenyl-butanoic acid 
• 81926-51-4 N-(tert-butyloxycarbonyl)-(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester 
• 87304-15-2 (2S)-2-[[(2S,3R)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid 
• 246506-79-6 (S)-benzyl 2-((2S,3R)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanamido)-4-methylpentanoate 
• 246506-80-9 1-{1-[2-(3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutyrylamino)-4-methyl-pentanoyl]pyrrolidine-2-carbonyl}-pyrrolidine-2-carboxylic acid benzyl ester 
• 182699-39-4 (2S,3R)-methyl-2,3-epoxy-4-phenylbutanoic acid 
• 612096-23-8 (2R,3S)-3-Bromo-2-hydroxy-4-phenyl-butyric acid methyl ester 
• 172025-60-4 (2S,3R)-3-Azido-2-hydroxy-4-phenyl-butyric acid methyl ester 
• 56610-42-5 L-prolyl-L-proline benzyl ester 
• 18942-49-9 Boc-D-Phe-OH 
• 246506-75-2 [1-benzyl-3-cyano-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-carbamic acid tert-butyl ester 
• 246506-78-5 2-(3-tert-butoxycarbonylamino-2-oxo-4-phenylbutyrylamino)-4-methylpentanoic acid benzyl ester 

Relevant articles and documents

New stereoselective synthesis of the peptidic aminopeptidase inhibitors bestatin, phebestin and probestin

Peptidic aminopeptidase inhibitors, bestatin, phebestin and probestin have been prepared by stereo- and regiocontrolled reactions from a common α,β-epoxy ester precursor.

Synthesis of the peptidic α-hydroxy amides phebestin, probestin, and bestatin from α-keto amide precursors

Aminopeptidase inhibitors, phebestin, probestin and bestatin have been prepared by stereospecific reduction of α-keto amide precursors using zinc borohydride.