81926-51-4

Basic information

• Product Name: N-(tert-butyloxycarbonyl)-(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester
• Synonyms: N-(tert-butyloxycarbonyl)-(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester
• CAS NO: 81926-51-4
• Molecular Weight: 309.362
• Mol File: 81926-51-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(tert-butyloxycarbonyl)-(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-butyloxycarbonyl)-(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester(81926-51-4)
• EPA Substance Registry System: N-(tert-butyloxycarbonyl)-(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester(81926-51-4)

Safety Data

• Hazardous Substances Data: 81926-51-4(Hazardous Substances Data)

Upstream product

• 74-88-4 methyl iodide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 172025-60-4 (2S,3R)-3-Azido-2-hydroxy-4-phenyl-butyric acid methyl ester 
• 67-56-1 methanol 
• 182699-39-4 (2S,3R)-methyl-2,3-epoxy-4-phenylbutanoic acid 
• 612096-23-8 (2R,3S)-3-Bromo-2-hydroxy-4-phenyl-butyric acid methyl ester 
• 64920-29-2 2-oxo-4-phenylbutanoic acid ethyl ester 
• 791052-06-7 (2R,3S)-3-Amino-2-hydroxy-4-phenyl-butyric acid ethyl ester 
• 1027661-56-8 C₂₈H₂₈N₂O₇ 
• 412941-20-9 C₂₈H₃₀N₂O₇ 
• 13033-84-6 D-phenylalanine methyl ester hydrochloride 
• 870-50-8 di-tert-butyl-diazodicarboxylate 
• 1334163-98-2 C₂₂H₃₄N₂O₇ 
• 124-41-4 sodium methylate 

Downstream Products

• 204460-76-4 (4R,5S)-4-Benzyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester 
• 145902-56-3 tert-Butyl (4R,5S)-4-benzyl-5-(((2S)-1-(tert-butoxy)-4-methyl-1-oxopentan-2-yl)-carbamoyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 139397-07-2 (4R,5S)-4-benzyl-3-[(tert-butoxy)carbonyl]-2,2-dimethyl-1,3-oxazolidine-5-carboxylic acid 
• 114886-76-9 (2(S)-hydroxy-3(R)-amino-4-phenylthiobutanoyl)-L-leucine trifluoroacetate 
• 246506-80-9 1-{1-[2-(3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutyrylamino)-4-methyl-pentanoyl]pyrrolidine-2-carbonyl}-pyrrolidine-2-carboxylic acid benzyl ester 
• 612096-25-0 (S)-1-{(S)-1-[(S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carbonyl}-pyrrolidine-2-carboxylic acid 
• 217480-75-6 2-(6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoylamino)-3-phenylpropionic acid benzyl ester 
• 123652-87-9 1-{1-[2-(3-amino-2-hydroxy-4-phenylbutyrylamino)-4-methyl-pentanoyl]pyrrolidine-2-carbonyl}-pyrrolidinme-2-carboxylic acid 
• 217480-76-7 (S)-2-[(S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid 
• 246506-79-6 (S)-benzyl 2-((2S,3R)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanamido)-4-methylpentanoate 
• 246506-77-4 6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoic acid benzyl ester 
• 87304-15-2 (2S)-2-[[(2S,3R)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid 
• 612096-24-9 (S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-3-methyl-butyric acid 
• 187402-73-9 2-[2-(3-amino-2-hydroxy-4-phenylbutyrylamino)-3-methylbutyrylamino]-3-phenylpropionic acid 

Relevant articles and documents

Direct enantioselective amination of α-ketoesters catalyzed by an axially chiral guanidine base

β-functional! Direct enantioselective amination of α-ketoesters with azodicarboxylates was demonstrated using an axially chiral guanidine base catalyst, which enabled efficient access to enantioenriched multifunctionalized ketoesters with an aliphatic substituent at the β-position. Subsequent nucleophilic addition to the β-hydrazinyl-α-ketoester at the reactive ketone yields the corresponding β-hydrazinyl-α-hydroxy esters in high syn diastereo- and enantioselectivities (see scheme).

Catalytic asymmetric direct α-amination reactions of 2-keto esters: A simple synthetic approach to optically active syn-β-amino-α-hydroxy esters

The catalytic enantioselective direct α-amination reaction of 2-keto esters with easily available azo dicarboxylates as the nitrogen source and chiral bisoxazoline-copper(II) complexes as the catalyst is presented. The reations proceed with excellent enan