123657-21-6Relevant articles and documents
NEW SYNTHESIS OF OXIME-TYPE BETA-LACTAM ANTIBIOTICS
Mandel, Martin,Novak, Ludvik,Rajsner, Miroslav,Holubek, Jiri,Hola, Vladislava
, p. 1734 - 1745 (2007/10/02)
Reacton of anhydrous acids II with phosphorus pentachloride afforded hydrochlorides of chlorides III which were used in acylations of N,O-bis(trimethylsilyl) derivatives of 6-aminopenicillanic acid and 7-aminodeacetoxycephalosporanic acid.Change of the (Z)-configuration of the alkoxyimino group during the synthesis was observed only in the methoxyimino series.The prepared penicillins IV are effective against gram-positive as well as gram-negative bacteria.