123664-34-6

Basic information

• Product Name: 3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one
• Synonyms: 3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one
• CAS NO: 123664-34-6
• Molecular Weight: 412.261
• Mol File: 123664-34-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one(123664-34-6)
• EPA Substance Registry System: 3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one(123664-34-6)

Safety Data

• Hazardous Substances Data: 123664-34-6(Hazardous Substances Data)

Upstream product

• 76838-72-7 5-methoxy-2-phenoxyaniline 
• 10298-80-3 2-chloro-5-methoxynitrobenzene 
• 123664-84-6 N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide 
• 123664-52-8 methyl 2-hydroxy-4-methylsulfonylamino-5-phenoxyphenyl ketone 
• 108-95-2 phenol 
• 123662-55-5 7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one 
• 84594-95-6 5-methoxy-1-nitro-2-phenoxybenzene 
• 123664-21-1 N-(4-oxo-6-phenoxy-2,3-dihydro-4H-7-chromenyl)methanesulfonamide 

Downstream Products

• 123663-48-9 N-(3-amino-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl)methanesulfonamide 
• 123663-49-0 Iguratimod 

Relevant articles and documents

Method for preparing high-yield and high-purity Iguratimod intermediate

The invention discloses a method for preparing an Iguratimod intermediate, i.e., 3-bromo-7-methsulfonamido-6-phenoxy-4H-1-benzo-2,3-dihydropyran-4-one. The method comprises the following steps: (1) dissolving cupric bromide in ethyl acetate and C1-C4 lower alkanol, and carrying out stirring for at least 30 minutes; (2) adding a dichloromethane solution of 7-sulfonamido-6-phenoxy-4H-1-benzo-2,3-dihydropyran-4-one into the solution obtained in the step (1), heating the temperature of the mixture to 20 DEG C to 50 DEG C with stirring, and performing a reaction for 2 to 6 hours; (3) carrying out filtering, washing filter liquor with an aqueous solution of sodium thiosulfate, and concentrating an organic phase, so as to obtain a crude product of the intermediate; and (4) carrying out refining with dichloromethane and petroleum ether, thereby obtaining a refined intermediate. The method is convenient in operation, high in conversion ratio and high in product purity, and the purity can reach96% or more.