123673-31-4

Upstream product

• 87219-29-2 benzyl (3S)-5-oxotetrahydro-3-furanylcarbamate 
• 4515-22-4 Z-D-Asp-anhydride 
• 75443-62-8 benzyl N-[(3R)-2,5-dioxotetrahydrofuran-3-yl]carbamate 
• 78663-07-7 N-(benzyloxycarbonyl)-D-aspartic acid 
• 4515-23-5 N-benzyloxycarbonyl-L-aspartic acid anhydride 
• 135517-09-8 ((1S,2R)-3-Benzylcarbamoyl-2-benzyloxycarbonylamino-1-hydroxymethyl-propyl)-carbamic acid tert-butyl ester 

Downstream Products

• 318249-44-4 Methylester of (R)-4-hydroxy-3-(benzyloxycarbonylamino) Butanoic Acid 
• 118399-28-3 (R)-4-benzyloxycarbonylamino-4,5-dihydro-2(3H)-furanone 
• 870812-29-6 benzyl (1R)-3-(dimethylamino)-1-(hydroxymethyl)-3-oxopropylcarbamate 
• 870812-30-9 benzyl {(1R)-3-(dimethylamino)-3-oxo-1-[(phenylthio)methyl]propyl}carbamate 
• 870812-92-3 benzyl (1R)-1-(hydroxymethyl)-3-(4-morpholinyl)-3-oxopropylcarbamate 
• 870812-93-4 benzyl (1R)-3-(4-morpholinyl)-3-oxo-1-((phenylsulfanyl)methyl)propylcarbamate 
• 1357575-01-9 (R)-methyl 3-(benzyloxycarbonylamino)-4-(phenylthio)butanoate 

Relevant academic research and scientific papers

INHIBITING B-CELL LYMPHOMA 2 (BCL-2) AND RELATED PROTEINS

Novel compounds inhibiting anti-apoptosis proteins B-cell lymphoma 2 (Bcl-2) and Bcl-XL include compounds of formula (I) and formula (II) disclosed herein, as well as liposome compositions comprising Bcl-2 inhibitor compounds. These compositions are usefu

CHEMICAL COMPOUNDS

The present invention relates to compounds of Formula (I): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit Bcl-2 and/or Bcl-XL activities and may be used for the treatment of cancer.

Highly Diastereoselective 1,4-Addition of Amines to Chiral α,β-Unsaturated δ-Lactone

Michael addition of amines to (S)-γ-amino-α,β-unsaturated δ-lactones was accomplished in extremely high diastereoselectivity with the ring-opening reactions and was disclosed to furnish (3R,4S)-diamino-hydroxyamides in high yields.

Synthesis of 3-Methoxy-2-iso-oxacephalosporin

Optically active 3-methoxy-2-iso-oxacephalosporins are efficiently prepared via intramolecular acylation as a key step.

Selective Reduction of Nα-Protected Dicarboxylic Amino Acid Anhydrides into Corresponding Protected Amino Alcohols

Nα-Protected dicarboxylic amino acid anhydrides, such as those of Z-D-Asp or Z-D-Glu have been selectively reduced in excellent yields with NaBH4 to give the corresponding Nα-protected amino alcohols.A probable mechanism for the sele