123707-40-4

Upstream product

• 100-52-7 benzaldehyde 
• 107-87-9 2-Pentanone 
• 7647-01-0 hydrogenchloride 
• 917-64-6 methyl magnesium iodide 
• 43209-86-5 3-trimethylsilyl-3-buten-2-one 

Downstream Products

• 61780-85-6 (R)-3-benzylpentan-2-one 
• 183003-17-0 (S)-3-ethyl-4-phenylbutan-2-one 
• 68226-05-1 r-2,cis-6-diphenyl-trans-3-ethyl-4-thianone 
• 63114-78-3 2-Aethyl-1,5-diphenyl-1,4-pentadien-3-on 
• 63114-79-4 (E)-1-(4-Nitro-phenyl)-4-[1-phenyl-meth-(Z)-ylidene]-hex-1-en-3-one 

Relevant academic research and scientific papers

Sequential Reactions of Michael Addition and Peterson Condensation of 1-Silylvinyl Ketones with Grignard Reagents: Study of Stereoselectivity

1-Silylvinyl ketones undergo smooth Michael addition with Grignard reagents generating magnesium enolates which are then trapped with benzaldehyde to give E- and Z-isomers of enones after Peterson condensation. (E)-Olefins become major products under a thermodynamic control when the condensation with benzaldehyde is carried out at room temperature in diethyl ether, while Z-isomers are more favored as kinetically controlled products at -78 deg C in THF.Reaction mechanism is briefly discussed.

RuCl3 catalyses aldol condensations of aldehydes and ketones

Anhydrous RuCl3 catalyses the efficient cross aldol condensations of different ketones with various aromatic aldehydes in sealed tube under solvent free conditions without the occurrence of any self condensations. Regioselective self condensation reaction of some ketones and aldehydes are also described. The catalytic effect of Ru(III) is shown by performing similar reactions under thermal conditions without catalyst.