123716-68-7

Upstream product

• 1773-12-2 3-Phenyl-4-methyl-4,5-dihydropyrazole 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 769-60-8 2-methyl-1-phenylprop-2-en-1-one 
• 16735-22-1 3-hydroxy-2-methylpropiophenone 
• 123716-81-4 3-Phenyl-4-methyl-4,5-dihydropyrazole hydrochloride 
• 59670-27-8 4-methoxybenzaldehyde N-acetylhydrazone 

Downstream Products

• 123716-70-1 1-Benzoyl-3-phenyl-4-methyl-4,5-dihydropyrazole 
• 1773-12-2 3-Phenyl-4-methyl-4,5-dihydropyrazole 
• 123716-81-4 3-Phenyl-4-methyl-4,5-dihydropyrazole hydrochloride 

Relevant academic research and scientific papers

Synthesis of pyrazolines by a site isolated resin-bound reagents methodology

The elaboration of biologically important 3,4-substituted pyrazolines was achieved by an organocatalysed aza-Michael/transimination domino sequence between hydrazones and enones making use of a mixture of heterogeneous resin-bound acid/base reagents. This methodology nicely illustrates the site isolation concept of supported reagents allowing the simultaneous use of otherwise destructive reactive functionalities. The Royal Society of Chemistry 2010.

Reinvestigation of the Reaction of 3-Hydroxy-2-methyl-1-aryl-1-propanones and Related Compounds with Hydrazine and Carboxylic Acids

The reaction between the title compounds and hydrazine hydrate in an appropriate carboxylic acid gave 1-acyl/aroyl-3-aryl-4-methyl-4,5-dihydropyrazoles 9, instead of 2,5,6-trisubstituted 6,7-dihydro-1,3,4-oxadiazepines as previously reported.Evidence is presented for the attribution of the correct structure and for the reaction mechanisms involved.