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769-60-8

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769-60-8 Usage

Description

2-methyl-1-phenyl-prop-2-en-1-one, also known as 2-methyl-1-phenyl-1-propen-1-one or cinnamaldehyde methyl ether, is an organic compound that features a phenyl group attached to a methyl-substituted prop-2-en-1-one moiety. It is characterized by its aromatic properties and reactivity, making it a versatile intermediate in organic synthesis.

Uses

Used in Pharmaceutical Industry:
2-methyl-1-phenyl-prop-2-en-1-one is used as a chemical reagent for the synthesis of various pharmaceutical agents, such as isoquinolines or tetrahydroquinolines. Its unique structure allows it to participate in a range of chemical reactions that facilitate the production of these bioactive compounds, which are important in the development of medications for treating various diseases and conditions.

Synthesis Reference(s)

Synthetic Communications, 17, p. 1823, 1987 DOI: 10.1080/00397918708077327Tetrahedron Letters, 21, p. 4283, 1980 DOI: 10.1016/S0040-4039(00)92884-3

Check Digit Verification of cas no

The CAS Registry Mumber 769-60-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,6 and 9 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 769-60:
(5*7)+(4*6)+(3*9)+(2*6)+(1*0)=98
98 % 10 = 8
So 769-60-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H10O/c1-8(2)10(11)9-6-4-3-5-7-9/h3-7H,1H2,2H3

769-60-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-methyl-1-phenylprop-2-en-1-one

1.2 Other means of identification

Product number -
Other names phenyl isopropenyl ketone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:769-60-8 SDS

769-60-8Relevant articles and documents

A Novel Synthesis of β-Trichlorostannyl Ketones from Siloxycyclopropanes and Their Facile Dehydrostannation Affording 2-Methylene Ketones

Ryu, Ilhyong,Murai, Shinji,Sonoda, Noboru

, p. 2389 - 2391 (1986)

Site-selective ring cleavage of siloxycyclopropanes 2 with stannic chloride (SnCl4) leads to good yields of β-trichlorostannyl ketones 3.Subsequent treatment of 3 with dimethyl sulfoxide (Me2SO) in chloroform at 60 deg C results in the facile dehydrostannation to give good yields of 2-methylene ketones 4.

Chemoselective reduction of ?,¢-unsaturated carbonyl and carboxylic compounds by hydrogen iodide

Matsumoto, Shoji,Marumoto, Hayato,Akazome, Motohiro,Otani, Yasuhiko,Kaiho, Tatsuo

, p. 590 - 599 (2021/03/29)

The selective reduction of ?,¢-unsaturated carbonyl compounds was achieved to produce saturated carbonyl compounds with aqueous HI solution. The introduction of an aryl group at an ? or ¢ position efficiently facilitated the reduction with good yield. The reaction was applicable to compounds bearing carboxylic acids and halogen atoms. Through the investigation of the reaction mechanism, it was found that Michael-type addition of iodide occurred to produce ¢-iodo compounds followed by the reduction of C-I bond via anionic and radical paths.

Merging Halogen-Atom Transfer (XAT) and Cobalt Catalysis to Override E2-Selectivity in the Elimination of Alkyl Halides: A Mild Route towardcontra-Thermodynamic Olefins

Zhao, Huaibo,McMillan, Alastair J.,Constantin, Timothée,Mykura, Rory C.,Juliá, Fabio,Leonori, Daniele

supporting information, p. 14806 - 14813 (2021/09/18)

We report here a mechanistically distinct tactic to carry E2-type eliminations on alkyl halides. This strategy exploits the interplay of α-aminoalkyl radical-mediated halogen-atom transfer (XAT) with desaturative cobalt catalysis. The methodology is high-yielding, tolerates many functionalities, and was used to access industrially relevant materials. In contrast to thermal E2 eliminations where unsymmetrical substrates give regioisomeric mixtures, this approach enables, by fine-tuning of the electronic and steric properties of the cobalt catalyst, to obtain high olefin positional selectivity. This unprecedented mechanistic feature has allowed access tocontra-thermodynamic olefins, elusive by E2 eliminations.

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