1237714-89-4

Basic information

• Product Name: N-((1R,3S)-3-hydroxycyclohexyl)-5-(4-(trifluoromethyl)phenyl)-4-(((S)-1,1,1-trifluoropropan-2-ylamino)methyl)isoxazole-3-carboxamide
• CAS NO: 1237714-89-4
• Molecular Weight: 479.422
• Mol File: 1237714-89-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-((1R,3S)-3-hydroxycyclohexyl)-5-(4-(trifluoromethyl)phenyl)-4-(((S)-1,1,1-trifluoropropan-2-ylamino)methyl)isoxazole-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-((1R,3S)-3-hydroxycyclohexyl)-5-(4-(trifluoromethyl)phenyl)-4-(((S)-1,1,1-trifluoropropan-2-ylamino)methyl)isoxazole-3-carboxamide(1237714-89-4)
• EPA Substance Registry System: N-((1R,3S)-3-hydroxycyclohexyl)-5-(4-(trifluoromethyl)phenyl)-4-(((S)-1,1,1-trifluoropropan-2-ylamino)methyl)isoxazole-3-carboxamide(1237714-89-4)

Safety Data

• Hazardous Substances Data: 1237714-89-4(Hazardous Substances Data)

Upstream product

• 854015-40-0 4-methyl-5-(4-trifluoromethyl phenyl)-isoxazole-3-carboxylic acid ethyl ester 
• 1237714-73-6 ethyl 4-(bromomethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate 
• 1237714-78-1 4-(hydroxymethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylic acid 
• 1237714-83-8 4-(chloromethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride 
• 125278-10-6 (S)-1,1,1-trifluoropropan-2-amine 
• 1304062-21-2 C₁₈H₁₈ClF₃N₂O₃ 

Relevant articles and documents

Identification of potent, soluble, and orally active TRPV1 antagonists

Optimization of a water soluble, moderately potent lead series of isoxazole-3-carboxamides was conducted, affording a compound with the requisite balance of potency, solubility and physicochemical properties for in vivo use. Compound 8e was demonstrated to be efficacious in a rat model of inflammatory pain, following oral administration.