123794-15-0Relevant articles and documents
New 5-nitroimidazoles bearing lactame nucleus: Synthesis and antibacterial properties
Jentzer,Vanelle,Crozet,Maldonado,Barreau
, p. 687 - 697 (2007/10/02)
New 5-nitroimidazoles bearing a trisubstituted ethylenic double bond in position 2 were prepared by reacting various 1-alkyl-2-chloromethyl-5-nitroimidazole with 3-nitrolactam anions by S(RN)1 mechanism in phase-transfer catalysis conditions. These compounds showed in vitro and in vivo antianaerobic activity which was clearly greater than that of metronidazole. Structure-activity relationships have been discussed.