123802-17-5

Upstream product

• 117248-23-4 (3RS,4S)-4-amino-6-methylhept-1-en-3-ol 
• 501-53-1 benzyl chloroformate 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 100841-17-6 4-methyl-2(S)-<(triphenylmethyl)amino>-1-pentanol 
• 107600-13-5 4-methyl-2(S)-<(triphenylmethyl)amino>-1-pentanal 
• 107599-94-0 3-hydroxy-6-methyl-4(S)-<(triphenylmethyl)amino>-1-heptene 
• 70853-26-8 N-carbobenzoxy-L-leucinal 
• 1826-67-1 vinyl magnesium bromide 
• 70853-26-8 O-benzyl-N-(4-methyl-1-oxopentan-2-yl)carbamid acid 
• 16369-17-8 2-amino-4-methylpentan-1-ol 
• 166735-51-9 (+/-)-2-[(Benzyloxycarbonyl)amino]-4-methylpentan-1-ol 

Downstream Products

• 132065-40-8 (2RS,4S,5RS)-3-benzyloxycarbonyl-4-isobutyl-2-phenylselenanylmethyl-5-vinyloxazolidine 
• 132065-40-8 3-benzyloxycarbonyl-4-isobutyl-2-phenylselenanylmethyl-5-vinyloxazolidine 
• 145632-69-5 (+/-)-1-benzyloxycarbonyl-7-isobutyl-1,3,4,7-tetrahydroazepin-2-one 
• 132065-54-4 C₂₄H₂₉NO₄Se 
• 145576-78-9 (+/-)-Benzyloxycarbonyl-8-methyl-3,4,7,8-tetrahydroazocin-2(1H)-one 
• 132065-54-4 C₂₄H₂₉NO₄Se 
• 132065-42-0 (7S)-1-benzyloxycarbonyl-7-isobutyl-1,3,4,7-tetrahydroazepin-2-one 

Relevant academic research and scientific papers

New Synthetic Methodology for the Synthesis of 7-Substituted Tetrahydroazepin-2-ones

The Claisen rearrangement of the vinyl substituted ketene aminals 2 (R = CH2CHMe2, CH2OSit-BuMe2) which were generated in situ by selenoxide elimination of the aminal precursors 3 in the presence of 1,8-diazabicycloundec-7-ene (DBU) furnished the enantiomerically pure 7-substituted tetrahydroazepin-2-ones 1.

N-ACYLAMINO ACID DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS

An N-acylamino acid derivative of the formula: STR1 wherein the substituents are herein defined or a salt thereof, which is useful as hypotensive drugs.

Synthesis Of Homochiral Unsaturated Seven-Membered Lactams

The Claisen rearrangement of the vinyl substituted ketene aminals 6 which were generated in situ by selenoxide elimination of the aminal precursors 5 in the presence of 1,8-diazabicycloundec-7-ene (DBU) gave the homochiral unsaturated seven-membere