145632-69-5

Upstream product

• 166735-51-9 (+/-)-2-[(Benzyloxycarbonyl)amino]-4-methylpentan-1-ol 
• 123802-17-5 4-benzyloxycarbonylamino-6-methylhept-1-en-3-ol 
• 501-53-1 benzyl chloroformate 
• 70853-26-8 O-benzyl-N-(4-methyl-1-oxopentan-2-yl)carbamid acid 
• 16369-17-8 2-amino-4-methylpentan-1-ol 
• 132065-40-8 3-benzyloxycarbonyl-4-isobutyl-2-phenylselenanylmethyl-5-vinyloxazolidine 
• 132065-54-4 C₂₄H₂₉NO₄Se 

Downstream Products

• 145576-92-7 (3R,7R)-3-Acetylamino-7-isobutyl-2-oxo-2,3,4,7-tetrahydro-azepine-1-carboxylic acid benzyl ester 
• 145576-90-5 (3R,7R)-7-Isobutyl-2-oxo-3-phenylselanyl-2,3,4,7-tetrahydro-azepine-1-carboxylic acid benzyl ester 
• 145576-90-5 (3S,7R)-7-Isobutyl-2-oxo-3-phenylselanyl-2,3,4,7-tetrahydro-azepine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

New Synthetic Methodology for the Synthesis of 7-Substituted Tetrahydroazepin-2-ones

The Claisen rearrangement of the vinyl substituted ketene aminals 2 (R = CH2CHMe2, CH2OSit-BuMe2) which were generated in situ by selenoxide elimination of the aminal precursors 3 in the presence of 1,8-diazabicycloundec-7-ene (DBU) furnished the enantiomerically pure 7-substituted tetrahydroazepin-2-ones 1.

Synthesis of Monocyclic Medium Ring Lactams

The Claisen rearrangement of the vinyl substituted ketene aminals 4a-c which were generated in situ by selenoxide elimination of the aminal precursors 3a-c in the presence of 1,8-diazabicycloundec-7-ene gave the monocyclic unsaturated medium ring l