123811-75-6 Usage
General Description
4-(tert-Butyl)picolinic acid hydrochloride is a chemical compound with the molecular formula C12H17ClN2O2. It is a derivative of picolinic acid, which is a derivative of pyridine. 4-(tert-Butyl)picolinic acid hydrochloride is often used in pharmaceutical research and drug development due to its potential pharmacological properties. It is known to have moderate to high affinity for choline binding sites in the brain, making it a potential candidate for the development of drugs that target these sites. Additionally, it has been studied for its potential neuroprotective and antioxidant properties. Overall, 4-(tert-Butyl)picolinic acid hydrochloride is a promising compound in the field of medicinal chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 123811-75-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,8,1 and 1 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 123811-75:
(8*1)+(7*2)+(6*3)+(5*8)+(4*1)+(3*1)+(2*7)+(1*5)=106
106 % 10 = 6
So 123811-75-6 is a valid CAS Registry Number.
123811-75-6Relevant articles and documents
An Improved Synthesis of Homoproline and Derivatives
Shuman, Robert T.,Ornstein, Paul L.,Paschal, Jonathan W.,Gesellchen, Paul D.
, p. 738 - 741 (2007/10/02)
An improved, general synthesis of substituted homoprolines has been developed by using readily available substituted pyridines (1).A key step in this synthetic procedure involves the known conversion of pyridine-N-oxides to 2-cyanopyridines (3) in nearly quantitative yields.The resulting nitriles are hydrolyzed to the corresponding pyridine-2-carboxylic acids (4).Subsequent reduction of the aromatic ring with PtO2/H2 gives the homoprolines (5) in good yields as racemic cis isomers.This procedure also can be utilized for the preparation of 5,6-benzohomoprolines fromthe appropriate quinoline precursors.The N-tert-butyloxycarbonyl (Boc) derivatives of these amino acids (useful intermediates for peptide synthesis) were also prepared in good yields.
