1239313-07-5Relevant academic research and scientific papers
Cooperative catalysis by palladium-nickel binary nanocluster for suzuki-miyaura reaction of ortho-heterocycle-tethered sterically hindered aryl bromides
Seth, Kapileswar,Purohit, Priyank,Chakraborti, Asit K.
, p. 2334 - 2337 (2014/05/20)
The palladium-nickel binary nanocluster is reported as a new catalyst system for Suzuki-Miyaura cross-coupling of ortho-heterocycle-tethered sterically hindered aryl bromides. The inferior results obtained with the reported Pd/Ni salts/complexes or individual Pd/Ni nanoparticles as catalyst reveal the cooperative catalytic effect of the Pd and Ni nanoparticles in the Pd-Ni nanocluster. The broad substrate scope with respect to variation of the 2-arylbenzoxazole moiety and boronic acids, which offers a means for diversity generation and catalyst recyclability, marks a distinct advantage.
2-(2-Arylphenyl)benzoxazole as a novel anti-inflammatory scaffold: Synthesis and biological evaluation
Seth, Kapileswar,Garg, Sanjeev K.,Kumar, Raj,Purohit, Priyank,Meena, Vachan S.,Goyal, Rohit,Banerjee, Uttam C.,Chakraborti, Asit K.
, p. 512 - 516 (2014/06/09)
The 2-(2-arylphenyl)benzoxazole moiety has been found to be a new and selective ligand for the enzyme cyclooxygenase-2 (COX-2). The 2-(2-arylphenyl)benzoxazoles 3a-m have been synthesized by Suzuki reaction of 2-(2-bromophenyl)benzoxazole. Further synthetic manipulation of 3f and 3i led to 3o and 3n, respectively. The compounds 3g, 3n, and 3o selectively inhibited COX-2 with selectivity index of 3n much better than that of the COX-2 selective NSAID celecoxib. The in vivo anti-inflammatory potency of 3g and 3n is comparable to that of celecoxib and the nonselective NSAID diclofenac at two different doses, and 3o showed better potency compared to these clinically used NSAIDs.
