123932-46-7

Upstream product

• 124831-36-3 N-[(2R,3S)-2-(2-Furan-2-yl-ethyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide 
• 99333-65-0 1-benzyl-3β-((S)-2-oxo-4-phenyloxazolidin-3-yl)-4β-[2-(2-furyl)ethyl]azetidin-2-one 
• 124831-38-5 cis-β,4-dioxo-3-[(phenoxyacetyl)amino]-2-azetidinepentanoic acid, (4-nitrophenyl)methyl ester 
• 124831-37-4 cis-4-oxo-3-[(phenoxyacetyl)amino]-2-azetidinepropanoic acid 
• 143738-49-2 (6R,7S)-3-Chloro-7-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 116806-16-7 (6R,7S)-7-Amino-3-chloro-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 143738-49-2 (R)-3-Chloro-7-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 119892-46-5 p-nitrobenzyl 7β-[(phenoxyacetyl)amino]-3-hydroxy-1-carba-1-dethia-3-cephem-4-carboxylate 
• 119892-48-7 cis-α-diazo-β,4-dioxo-3-[(phenoxyacetyl)amino]-2-azetidinepentanoic acid, (4-nitrophenyl)methyl ester 

Downstream Products

• 124620-59-3 4-nitrobenzyl 7β-<amino>-1-carba-3-chloro-3-cephem-4-carboxylate 
• 124620-60-6 4-nitrobenzyl 7β-(D-phenylglycylamino)-1-carba-3-chloro-3-cephem-4-carboxylate 
• 124620-62-8 4-nitrobenzyl 7β-<amino>-1-carba-3-chloro-3-cephem-4-carboxylate 
• 76470-66-1 loracarbef 
• 153502-34-2 (7S,6R)-7-<<2-<(tritylamino)-4-thiazolyl>trityloximinoacetyl>amino>-3-chloro-1-carba-1-dethia-3-cephem-4-carboxylic acid 
• 153502-35-3 (7S,6R)-7-<<(2-amino-4-thiazolyl)hydroximinoacetyl>amino>-3-chloro-1-carba-1-dethia-3-cephem-4-carboxylic acid 
• 153502-32-0 p-nitrobenzyl (7S,6R)-7-<<2-<(tritylamino)-4-thiazolyl>trityloximinoacetyl>amino>-3-chloro-1-carba-1-dethia-3-cephem-4-carboxylate 
• 153756-43-5 Mono<amino>succinyl>-N-(benzyloxy)amino>butyl> bis<butyl> isocyanurate 
• 124831-39-6 (6R,7S)-3-Chloro-7-[(R)-2-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-2-phenyl-acetylamino]-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 124620-61-7 4-nitrobenzyl 7β-<amino>-1-carba-3-chloro-3-cephem-4-carboxylate 

Relevant academic research and scientific papers

The synthesis of 7α-amidocarbacephems

Study of compounds related to the first clinically-investigated 7β-amidocarbacephem, loracarbef (1), led to the preparation of key 7α-amidocarbacephem derivatives. The synthesis, characterization, and biological properties of these compounds are reported.

AN ENANTIOSELECTIVE SYNTHESIS OF LORACARBEF (LY163892/KT3777)

An enantioselective synthesis of the new, orally absorbable, totally synthetic β-lactam antibiotic, loracarbef(LY163892/KT3777) is described.