1239481-05-0Relevant academic research and scientific papers
Introduction of an Oxidation-responsive 4-Boronobenzyl Group into an Oligonucleotide through a Postmodification Approach
Hanifah, Sharina Abu,Higashi, Sayuri L.,Ikeda, Masato,Kawaki, Yugo,Kitamura, Yoshiaki,Shibata, Aya,Shirakami, Nanami,Wah, Lim Lee
supporting information, p. 1412 - 1415 (2021/08/03)
Oxidation-responsive oligonucleotides (ONs) can exhibit controlled functions by sensing dysregulated oxidation conditions in living systems. Herein, we describe a postmodification approach to constructing an oxidation-responsive ON that takes advantage of the reactivity of diazo compounds in introducing a 4-boronobenzyl group to a phosphate group at a 5 -terminal of an ON.
Convenient Entry to 18F-Labeled Amines through the Staudinger Reduction
Stéen, E. Johanna L.,Shalgunov, Vladimir,Denk, Christoph,Mikula, Hannes,Kj?r, Andreas,Kristensen, Jesper L.,Herth, Matthias M.
supporting information, p. 1722 - 1725 (2019/01/30)
Fluorine-18 possesses outstanding decay characteristics for positron emission tomography (PET) imaging. Therefore, it is ideally suited for clinical applications. As such, improved strategies to incorporate fluorine-18 into bioactive molecules are of utmo
[3 + 3] Cycloaddition of azides with in situ formed azaoxyallyl cations to synthesize 1,2,3,4-Tetrazines
Xu, Xiaoying,Zhang, Kaifan,Li, Panpan,Yao, Hequan,Lin, Aijun
supporting information, p. 1781 - 1784 (2018/04/14)
A formal [3 + 3] cycloaddition reaction between azides and in situ formed azaoxyallyl cations has been realized. This reaction provided an efficient and practical pathway to synthesize 1,2,3,4-tetrazines in good yields under mild conditions. Biologically active molecules could also be well compatible, highlighting the potential value of this reaction.
A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions
White, James R.,Price, Gareth J.,Schiffers, Stefanie,Raithby, Paul R.,Plucinski, Pawel K.,Frost, Christopher G.
supporting information; experimental part, p. 3913 - 3917 (2010/08/22)
The stable benzylazido-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions.
