123983-05-1

Basic information

• Product Name: Phenol, 2-[(1R)-1-aminoethyl]-
• Synonyms: Phenol, 2-[(1R)-1-aminoethyl]-;2-[(1R)-1-aMinoethyl]-
• CAS NO: 123983-05-1
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.18
• Product Categories: API intermediates
• Mol File: 123983-05-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 83 °C
• Boiling Point: 246.289°C at 760 mmHg
• Flash Point: 102.752°C
• Appearance: /
• Density: 1.097g/cm³
• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.99±0.35(Predicted)
• CAS DataBase Reference: Phenol, 2-[(1R)-1-aminoethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-[(1R)-1-aminoethyl]-(123983-05-1)
• EPA Substance Registry System: Phenol, 2-[(1R)-1-aminoethyl]-(123983-05-1)

Safety Data

• Hazardous Substances Data: 123983-05-1(Hazardous Substances Data)

Usage

General Description

Phenol, 2-[(1R)-1-aminoethyl]- is a chemical compound with the molecular formula C8H11NO. It is a derivative of phenol with an added aminoethyl group. Phenol, 2-[(1R)-1-aminoethyl]- is a colorless to slightly yellow liquid with a slightly sweet odor. It is primarily used in the production of pharmaceuticals, particularly as a precursor for the synthesis of various drugs and medications. It also has applications in the manufacturing of agrochemicals, dyes, and polymers. Additionally, it can be utilized as a reagent in organic synthesis and as a specialty solvent. Due to its potential health hazards, including skin and eye irritation, respiratory tract irritation, and central nervous system effects, proper safety precautions should be taken when handling this chemical.

InChI:InChI=1/C8H11NO/c1-6(9)7-4-2-3-5-8(7)10/h2-6,10H,9H2,1H3/t6-/m1/s1

Upstream product

• 40023-74-3 (R)-1-(2-methoxyphenyl)ethylamine 
• 223268-30-2 2-<(1R)-1-(<(1'R)-1'-phenylethyl>amino)ethyl>phenol 
• 21895-22-7 2’-hydroxyacetophenone imine 
• 89985-53-5 1-(2-hydroxyphenyl)ethylamine 
• 702684-14-8 (-)-(βR)-β-{[(1R)-(2-methoxyphenyl)ethyl]amino}benzeneethanol 
• 702684-12-6 (-)-(βR)-β-{[(1E)-(2-methoxyphenyl)methylene]amino}benzeneethanol 
• 95255-51-9 (-)-2-{1-{[(1R)-1-phenylethyl]imino}ethyl}phenol 
• 135-02-4 ortho-anisaldehyde 
• 118-93-4 o-hydroxyacetophenone 
• 368447-75-0 (2S)-2-[({(1R)-1-[2-(methoxymethoxy)phenyl]ethyl}amino)oxy]-2-phenylethanol 
• 368447-69-2 2-methoxymethoxybenzaldehyde (E)-O-[(1S)-2-hydroxy-1-phenylethyl]oxime 
• 368447-78-3 (1R)-1-[2-(methoxymethoxy)phenyl]ethanamine 

Downstream Products

• 1637438-76-6 C₂₁H₂₀N₄O₂ 
• 220768-01-4 (R)-1-[(R)-1-(2-Methoxy-phenyl)-ethyl]-6-(2-oxo-propyl)-6-pentyl-piperidin-2-one 
• 220768-12-7 (R)-6-Allyl-1-[(R)-1-(2-methoxy-phenyl)-ethyl]-6-pentyl-piperidin-2-one 
• 220768-00-3 (R)-6-Allyl-1-[(R)-1-(2-hydroxy-phenyl)-ethyl]-6-pentyl-piperidin-2-one 
• 327158-13-4 (R)-6-Allyl-1-[(R)-1-(2-hydroxy-phenyl)-ethyl]-piperidin-2-one 
• 327158-15-6 {(R)-1-[(R)-1-(2-Methoxy-phenyl)-ethyl]-6-oxo-piperidin-2-yl}-acetaldehyde 
• 327158-11-2 1-[(R)-1-(2-Hydroxy-phenyl)-ethyl]-piperidine-2,6-dione 

Relevant articles and documents

Design and synthesis of chiral oxathiozinone scaffolds: Efficient synthesis of hindered enantiopure sulfinamides and sulfinyl ketimines

Is that S-O? The title scaffolds have a highly active and properly differentiated S-O bond for the efficient synthesis of enantiopure sulfinamides. The method is practical, green, and has the potential to provide an economical commercial process for the synthesis of bulky sulfinamides. Copyright

Enantioselective synthesis of primary 1-(aryl)alkylamines by nucleophilic 1,2-addition of organolithium reagents to hydroxyoxime ethers and application to asymmetric synthesis of G-protein-coupled receptor ligands

(E)-Arylaldehyde oxime ethers bearing a (1S)-2-hydroxy-1-phenylethyl or (2R)-1-hydroxy-2-phenylethyl group as a chiral auxiliary, both derived from a single precursor, methyl (R)-mandelate, underwent nucleophilic addition with organolithium reagents via six-membered chelates to give the diastereomerically enriched (R)- and (S)-adducts, respectively, which, after chiral auxiliary removal by reductive N-O bond cleavage, led to the corresponding (R)- and (S)-1-(aryl)ethylamines. This organolithium addition protocol using methyllithium was applied in an enantiodivergent fashion to the preparation of both enantiomers of 1-(2-hydroxyphenyl)ethylamine, which has been previously used as an efficient chiral auxiliary for the synthesis of natural products in this laboratory. The synthetic utility of this methodology involving diastereoselective methyl addition was demonstrated by further application to the asymmetric synthesis of a new type of calcium receptor agonist (calcimimetics), (R)-(+)-NPS R-568 and its thio analogue. Furthermore, diastereoselective vinylation was accomplished by application of the hydroxy oxime ether-based protocol using vinyllithium, which allowed the development of the enantioselective synthesis of the NK-1 receptor antagonists, (+)-CP-99,994 and (+)-CP-122,721.