123992-29-0

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 123992-28-9 (2R,3R,4S,5S,6R,8S,9S,10R,11R,12S)-3,5,9,11-Tetrakis-benzyloxy-13-(tert-butyl-diphenyl-silanyloxy)-2,4,6,8,10,12-hexamethyl-tridecanal 
• 36019-62-2 2,3-Dihydro-3,5-dimethyl-4H-pyran-4-one (Pyrone 4) 
• 124095-53-0 Methyl 2,4-Dideoxy-2,4-dimethyl-α-L-xylopyranoside (Pyran 6) 
• 123992-05-2 cis/trans-(+/-)-5,6-Dihydro-2-methoxy-3,5-dimethyl-2H-pyran (Pyran 5) 
• 123992-07-4 2,4-Dideoxy-2,4-dimethyl-L-xylose Cyclic 1,3-Propanediyl Mercaptal (Diol 7) 
• 98703-75-4 (E,Z)-3-<(tert-butyldimethylsilyl)oxy>-1-methoxy-2-methyl-1,3-pentadiene 
• 123992-27-8 <2S-(2R*,3R*,4R*,5R*,6S*,8R*,9R+,10S*,11S*,12R*)>-13-<<(1,1-Dimethylethyl)diphenylsilyl>oxy>-2,4,6,8,10,12-hexamethyl-3,5,9,11-tetrakis(phenylmethoxy)-1-tridecanol (Alcohol 36) 
• 123992-18-7 <2S-<2α(1S*,3R*,4R*,5S*,6S*,7R*),3β>>-2-<8-<<(1,1-Dimethylethyl)diphenylsilyl>oxy>-1,3,5,7-tetramethyl-4,6-bis(phenylmethoxy)octyl>-2,3-dihydro-3,5-dimethyl-4H-pyran-4-one (Pyrone 18) 
• 123992-24-5 <4R-(2Z,4R*,5S*,6R*,8S*,9S*,10R,11R*,12S*)>-13-<<(1,1-Dimethylethyl)diphenylsilyl>oxy>-2,4,6,8,10,12-hexamethyl-5,9,11-tris(phenylmethoxy)-2-tridecenal (Z Enal 30) 
• 124095-55-2 <4R-(2E,4R*,5S*,6R*,8S*,9S*,10R*,11R*,12S*)>-13-<<(1,1-Dimethylethyl)diphenylsilyl>oxy>-2,4,6,8,10,12-hexamethyl-5,9,11-tris(phenylmethoxy)-2-tridecenal (E Enal 31) 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 123992-08-5 2,4-Dideoxy-5-O-<(1,1-dimethylethyl)diphenylsolyl>-2,4-dimethyl-L-xylose, Cyclic 1,3-Propanediyl Mercaptal (Alcohol 8) 
• 123992-30-3 <2S-(2R*,3S*,4S*,5R*,6R*,8S*,9R+,10R*,11R*,12R*,13S*)>-2,4,6,8,10,12-Hexamethyl-3,5,9,11-tetrakis(phenylmethoxy)-1,13-pentadecanediol (Diol 40) 

Downstream Products

• 123992-33-6 <5R-(5R*,6R*,7R*,8S*,9S*,10R*,12S*,13S*,14R*,15R*,16S*)>-5-Ethyl-2,2,3,3,6,8,10,12,14,16,20,20-dodecamethyl-19,19-diphenyl-7,9,13,15-tetrakis(phenylmethoxy)-4,18-dioxa-3,19-disilaheneicosane (Protected Hexaol 41) 

Relevant academic research and scientific papers

Development of a fully synthetic stereoselective route to 6-Deoxyerythronolide B by reiterative applications of the Lewis acid catalyzed diene aldehyde cyclocondensation reaction: A remarkable instance of diastereofacial selectivity

The synthesis of racemic 2, which contains the relative stereochemistry appropriate to a synthesis of (9S)-dihydro-6-deoxyerythronolide B (see compound 38), is described. The synthesis features three Lewis acid catalyzed diene aldehyde cyclocondensation r