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CAS

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123994-74-1

2-{[4-(trifluoromethyl)phenyl]amino}-3,7-dihydro-6H-purin-6-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 123994-74-1 Structure

  • Basic information

    1. Product Name: 2-{[4-(trifluoromethyl)phenyl]amino}-3,7-dihydro-6H-purin-6-one
    2. Synonyms: 1H-purin-6-ol, 2-[[4-(trifluoromethyl)phenyl]amino]-; 2-{[4-(trifluoromethyl)phenyl]amino}-1H-purin-6-ol
    3. CAS NO:123994-74-1
    4. Molecular Formula: C12H8F3N5O
    5. Molecular Weight: 295.22
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 123994-74-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 514.8°C at 760 mmHg
    3. Flash Point: 265.1°C
    4. Appearance: N/A
    5. Density: 1.68g/cm3
    6. Vapor Pressure: 1.05E-10mmHg at 25°C
    7. Refractive Index: 1.683
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-{[4-(trifluoromethyl)phenyl]amino}-3,7-dihydro-6H-purin-6-one(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-{[4-(trifluoromethyl)phenyl]amino}-3,7-dihydro-6H-purin-6-one(123994-74-1)
    12. EPA Substance Registry System: 2-{[4-(trifluoromethyl)phenyl]amino}-3,7-dihydro-6H-purin-6-one(123994-74-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 123994-74-1(Hazardous Substances Data)

123994-74-1 Usage

Type of Compound

Chemical compound with potential pharmacological activity

Type of Inhibitor

Selective Janus kinase (JAK) 1 and 2 inhibitor

Medical Use

Treatment of certain types of myelofibrosis and polycythemia vera (both rare bone marrow diseases)

Mechanism of Action

Inhibits the JAK-STAT signaling pathway, which plays a key role in the regulation of immune function and inflammation

Benefits

Shows promise in reducing symptoms and improving quality of life for patients with myelofibrosis and polycythemia vera

Importance

An important therapeutic option for individuals suffering from these rare blood disorders

Check Digit Verification of cas no

The CAS Registry Mumber 123994-74-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,9,9 and 4 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 123994-74:
(8*1)+(7*2)+(6*3)+(5*9)+(4*9)+(3*4)+(2*7)+(1*4)=151
151 % 10 = 1
So 123994-74-1 is a valid CAS Registry Number.

123994-74-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[4-(trifluoromethyl)anilino]-3,7-dihydropurin-6-one

1.2 Other means of identification

Product number -
Other names 6H-Purin-6-one,1,9-dihydro-2-[[4-(trifluoromethyl)phenyl]amino]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123994-74-1 SDS

123994-74-1Downstream Products

123994-74-1Relevant articles and documents

Structure-Activity Relationships of N2-Substituted Guanines as Inhibitors of HSV1 and HSV2 Thymidine Kinases

Hildebrand, Catherine,Sandoli, Daniele,Focher, Federico,Gambino, Joseph,Ciarrocchi, Giovanni,et al.

, p. 203 - 206 (2007/10/02)

A series of N2-phenylguanines was synthesized and tested for inhibition of the thymidine kinases encoded by Herpes simplex viruses type 1 and type 2.Compounds with hydrophobic, electron-attracting groups in the meta position of the phenyl ring

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