124093-43-2

Upstream product

• 591-87-7 Allyl acetate 
• 31042-20-3 7-(benzyloxy)chroman-4-one 
• 620-05-3 iodomethylbenzene 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 76240-27-2 7-hydroxy-2,3-dihydro-4H-chromen-4-one 
• 108-22-5 Isopropenyl acetate 

Downstream Products

• 26200-05-5 7-benzyloxy-isoflavanone 
• 31042-20-3 7-(benzyloxy)chroman-4-one 
• 124093-46-5 (E)-1-(4-Benzyloxy-2-hydroxy-phenyl)-2,3-diphenyl-propenone 
• 121884-61-5 7-benzyloxy-3,3-diphenylchroman-4-one 
• 59870-68-7 glabridin 
• 59870-70-1 (R)-3-(2,4-dimethoxyphenyl)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromene 
• 41743-86-6 Sativan 

Relevant academic research and scientific papers

Method for asymmetrically synthesizing glabridin with optical purity

The invention discloses a method for asymmetrically synthesizing glabridin with optical purity, belonging to the field of organic synthesis. According to the invention, 7-hydroxychroman-4-one is usedas a raw material and is subjected to seven successive reactions including a protecting group protection reaction, an enol esterification reaction, an asymmetric addition reaction, a carbonyl reduction reaction, a phenolic hydroxyl protecting group removal reaction, a cyclization reaction and a demethylation reaction so as to finally prepare glabridin with optical purity. The optically pure glabridin is obtained by asymmetrically introducing a chiral center by using a palladium catalyst and an organophosphorus ligand; reaction conditions are mild; operation is convenient; and the method is suitable for industrial application. The raw material is easy to obtain and low in cost, and the product is good in yield and high in stereoselectivity.

PALLADIUM CATALYSED ARYLATION OF CHROM-3-EN-4-OL ACETATES VIA THEIR TRIBUTYLTIN ENOLATES

Arylation of in situ generated chrom-3-en-4-ol tributyltin enolates with aryl bromide in the presence of a catalytic amount of PdCl22 gives moderate to good yields of the corresponding isoflavanones.