124150-94-3

Upstream product

• 40036-54-2 (E)-5-(3,3-dimethyloxiran-2-yl)-3-methylpent-2-en-1-ol 
• 67-64-1 acetone 
• 83377-03-1 (E)-6,7-O-isopropylidene-3,7-dimethyl-2-octene-1,6,7-triol-1-acetate 
• 154631-44-4 trans-3,7-Dimethyl-6,7-dihydroxy-2-octen-1-ol 
• 106-24-1 Geraniol 
• 79083-70-8 (E)-3-methyl-5-(3,3-dimethyloxiran-2-yl)pent-2-enal 
• 141-27-5 3,7-dimethyl-2,6-octadienal 
• 684217-05-8 6,7-dihydroxygeranyl N-phenylcarbonate acetonide 
• 37715-33-6 essigsaeure-<(E)-6,7-dihydroxy-3,7-dimethyl-2-octenyl>ester 
• 105-87-3 3,7-dimethyl-2E,6-octadien-1-yl acetate 

Downstream Products

• 83324-71-4 4,6-dichloro-2-<(E)-6',7'-dihydroxy-3',7'-dimethyl-2'-octenyl>-5-methyl-1,3-cyclohexanedione-6',7'-acetonide 
• 83324-72-5 4-chloro-2-<(E)-6',7'-dihydroxy-3',7'-dimethyl-2'-octenyl>orcinol-6',7'-acetonide 
• 83324-70-3 3-<(E)-6',7'-dihydroxy-3',7'-dimethyl-2'-octenyl>-2,4-dimethoxy-6-methyl-1,4-cyclohexadiene-6',7'-acetonide 
• 43043-16-9 (+/-)-colletochlorin A 
• 179618-59-8 5-[(3E,5E)-9-(4-Methoxy-benzyloxy)-3-methyl-nona-3,5-dienyl]-2,2,4,4-tetramethyl-[1,3]dioxolane 
• 179618-64-5 (4E,6E,10R)-10-methoxy-1-(4-methoxybenzyl)oxy-7-methyltrideca-4,6,12-triene 
• 179618-61-2 (6E,8E)-12-(4-Methoxy-benzyloxy)-2,6-dimethyl-dodeca-6,8-diene-2,3-diol 
• 179618-63-4 (4E,6E,10R)-10-hydroxy-1-(4-methoxybenzyl)oxy-7-methyltrideca-4,6,12-triene 
• 179618-62-3 (4E,6E)-10-(4-Methoxy-benzyloxy)-4-methyl-deca-4,6-dienal 
• 155233-30-0 curacin A 

Relevant academic research and scientific papers

142. 1,2-Epoxy-Carotinoide. 1. Mitteilung. Synthese von 1,2-Epoxy-lycopin und 1,2,1',2'-Diepoxy-lycopin

The synthesis of the naturally occuring 1,2-epoxy-lycopene and of 1,2,1',2'-diepoxy-lycopene is described.

Practical and efficient entry to isoflavones by Pd(0)/C-mediated Suzuki-Miyaura reaction. Total synthesis of geranylated isoflavones

A scalable synthesis of isoflavones taking advantage of the Suzuki-Miyaura reaction catalyzed by Pd(0)/C is described. The approach developed has been extended to the total synthesis of 7-O-geranylformononetin, griffonianone D, and conrauinone D, which did not display cytotoxicity against human HeLa carcinoma cells. In addition, this study established unambiguously the absolute configuration of natural griffonianone D.

SYNTHESIS OF SPIRO ORTHO ESTERS, SPIRO ORTHO CARBONATES, AND INTERMEDIATES

Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synt

A mild and selective deprotection of p-methoxybenzyl (PMB) ether by magnesium bromide diethyl etherate-methyl sulfide

The magnesium bromide diethyl etherate (MgBr2 · OEt2)-methyl sulfide (Me2S) system is useful for the mild and chemo-selective deprotection of p-methoxybenzyl (PMB) ether in the presence of 1,3-diene, t-butyldimethylsilyl (TBDMS) ether, benzoate, benzyl ether and acetonide.

Synthetic study on curacin A: A novel antimitotic agent from the cyanobacterium Lyngbya majuscula

Curacin A (1), a novel antimitotic agent, was synthesized in a highly stero-controlled manner. The four stereoisomers of a partial structure at the thiazoline moiety, 2 were also synthesized to aid in elucidation of the absolute configurations of three chiral centers in curacin A. The effects of porcine brain tubulin assembly of several synthetic compounds related to curacin A were examined.

Asymmetric total synthesis of curacin A

Curacin A (1), a novel antimitotic agent, was synthesized in a highly stereo-controlled manner. The key steps were (1) an asymmetric allylation using a chiral allyltitanium reagent and a double-asymmetric Simmons-Smith cyclopropanation to introduce three chiral centers, (2) Wittig and Wittig- Horner reactions to construct the C(3-4) and C(7-10) alkenes, and (3) a direct conversion of the thiazolidine to the thiazoline.

p-Anisyloxymethyl Group, a Novel Oxidatively Removable Acetal Type OH-Protecting Group

Protection of various types of alcohols with p-anisyloxymethyl (p-AOM) chloride gave the corresponding p-AOM ethers which were deprotected with ceric ammonium nitrate efficiently.Chemoselective removal either of p-AOM group or of tetrahydropyranyl group is also reported.

ELECTROGENERATED ACID AS A POWERFUL CATALYST FOR TRANSFORMATION OF EPOXIDES TO KETONES AND ACETONIDES

Electrochemical Transformation of epoxides 1 to ketones 2 and acetonides 3 were achieved by using an electrogenerated acid-catalyst.A combination of M(ClO4)n with polar aprotic solvents is useful for the electrochemical transformation.

A GENERAL SYNTHETIC METHOD FOR PRENYLATED PHENOLS OF MICROBIAL ORIGIN

Prenylated phenols with a fully substituted benzene ring, such as colletochlorins A and B, were synthesized by first prenylating 1,5-dimethoxy-3-methyl-1,4-cyclohexadiene and then effecting the aromatization of the prenylated product.