124153-81-7Relevant articles and documents
Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: Dual inhibitors of cyclooxygenases and lipoxygenases
Rao, P. N. Praveen,Chen, Qiao-Hong,Knaus, Edward E.
, p. 1668 - 1683 (2006)
A group of 1,3-diarylprop-2-yn-1-ones (13, 17, 23, 26 and 27) possessing a C-3 p-SO2Me COX-2 pharmacophore were designed, synthesized and evaluated as potential dual inhibitors of cyclooxygenase-1/2 (COX-1/2) and 5/15-lipoxygenases (5/15-LOX) t
Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers
Chowdhury, Morshed Alam,Dong, Ying,Chen, Qiao-Hong,Abdellatif, Khaled R.A.,Knaus, Edward E.
, p. 1948 - 1956 (2008/09/21)
A group of 1-(aminosulfonylphenyl and methylsulfonylphenyl)-2-(pyridyl)acetylene regioisomers were designed such that a COX-2 SO2NH2 pharmacophore was located at the para-position of the phenyl ring, or a SO2Me pharmacopho
Experimental and theoretical study of the dimetalation of phenylacetylene and (1-naphthyl)acetylene
Klusener,Hanekamp,Brandsma,Von Rague Schleyer
, p. 1311 - 1321 (2007/10/02)
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