124153-81-7Relevant academic research and scientific papers
Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: Dual inhibitors of cyclooxygenases and lipoxygenases
Rao, P. N. Praveen,Chen, Qiao-Hong,Knaus, Edward E.
, p. 1668 - 1683 (2006)
A group of 1,3-diarylprop-2-yn-1-ones (13, 17, 23, 26 and 27) possessing a C-3 p-SO2Me COX-2 pharmacophore were designed, synthesized and evaluated as potential dual inhibitors of cyclooxygenase-1/2 (COX-1/2) and 5/15-lipoxygenases (5/15-LOX) t
Pd/C-mediated coupling of aryl halides with terminal alkynes in water
Batchu, Venkateswara Rao,Subramanian, Venkataraman,Parasuraman, Karuppasamy,Swamy, Nalivela Kumara,Kumar, Sanjeev,Pal, Manojit
, p. 9869 - 9877 (2005)
2-Aminoethanol facilitated the alkynylation of aryl halides (Sonogashira reaction) under palladium/charcoal-copper catalysis in water affording a mild and practical method for the synthesis of arylalkynes. A variety of terminal alkynes were coupled with a
Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers
Chowdhury, Morshed Alam,Dong, Ying,Chen, Qiao-Hong,Abdellatif, Khaled R.A.,Knaus, Edward E.
, p. 1948 - 1956 (2008/09/21)
A group of 1-(aminosulfonylphenyl and methylsulfonylphenyl)-2-(pyridyl)acetylene regioisomers were designed such that a COX-2 SO2NH2 pharmacophore was located at the para-position of the phenyl ring, or a SO2Me pharmacopho
Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases
Rao, P.N. Praveen,Chen, Qiao-Hong,Knaus, Edward E.
, p. 4842 - 4845 (2007/10/03)
A new class of 1,3-diphenylprop-2-yn-1-ones possessing a p-MeSO2 COX-2 phamacophore on the C-3 phenyl ring was designed for evaluation as dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX). Among the group of compounds evaluated, 1-
