1242269-30-2

Basic information

• Product Name: ethyl 2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzoate
• Synonyms: ethyl 2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzoate
• CAS NO: 1242269-30-2
• Molecular Weight: 304.25
• Mol File: 1242269-30-2.mol

Chemical Properties

• CAS DataBase Reference: ethyl 2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzoate(1242269-30-2)
• EPA Substance Registry System: ethyl 2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzoate(1242269-30-2)

Safety Data

• Hazardous Substances Data: 1242269-30-2(Hazardous Substances Data)

Upstream product

• 179011-37-1 SRS₁₄-41 
• 359-13-7 difluoroethanol 
• 1219119-52-4 2-fluoro-4-methylamino-5-nitro-benzoic acid ethyl ester 

Downstream Products

• 1360624-51-6 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid 
• 1360622-16-7 N-(3-cyano-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide 
• 1360622-17-8 N-(2,4-dichloro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide 
• 1360624-40-3 ethyl 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid ester 
• 1360622-07-6 N-(4-bromo-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide 
• 1242269-31-3 ethyl 5-amino-2-(2,2-difluoroethoxy)-4-(methylamino)benzoate 

Relevant articles and documents

NEW COMPOUNDS

This invention relates to compounds of formula (I) their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R6, R7, R8 have meanings given in the description.

NEW COMPOUNDS

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R6, R7, R8 have meanings given in the description.

3H-IMIDAZO [4, 5 -C] PYRIDINE- 6 -CARBOXAMIDES AS ANTI- INFLAMMATORY AGENTS

The present invention relates to compounds of general formula (I) in which A, L, M, Q2, Q3, Q4, R1, R5, Ra, Rb, Rc, W, X, Y, Z1, Z2, Z3 are defined in the description, the salts thereof, particularly the physiologically acceptable salts thereof. The compounds are of potential utility in the treatment and/or prevention of inflammatory diseases and associated conditions, in particular, in the treatment and/or prevention of pain. The invention also relates to the use of such compounds as medicaments, to pharmaceutical compositions containing them, and to their preparation.