1360624-51-6

Basic information

• Product Name: 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid
• Synonyms: 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid
• CAS NO: 1360624-51-6
• Molecular Weight: 529.371
• Mol File: 1360624-51-6.mol

Chemical Properties

• CAS DataBase Reference: 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid(1360624-51-6)
• EPA Substance Registry System: 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid(1360624-51-6)

Safety Data

• Hazardous Substances Data: 1360624-51-6(Hazardous Substances Data)

Upstream product

• 1360624-40-3 ethyl 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid ester 
• 1360624-07-2 N-(3-nitro-2,4-dichloro-benzyl)-2,2-dimethyl-propionamide 
• 1360624-05-0 3-nitro-2,4-dichloro-benzylamine 
• 1360624-03-8 N-(3-nitro-2,4-dichloro-benzyl)-2,2,2-trifluoroacetamide 
• 1360624-01-6 N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide 
• 1360623-97-7 3-amino-2,4-dichloro-benzylamine 
• 1360623-95-5 3-amino-2,4-dichloro-benzamide 
• 1242269-30-2 ethyl 2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzoate 
• 1242269-31-3 ethyl 5-amino-2-(2,2-difluoroethoxy)-4-(methylamino)benzoate 
• 1219119-52-4 2-fluoro-4-methylamino-5-nitro-benzoic acid ethyl ester 
• 601-88-7 2,6-dichloronitrobenzene 
• 179011-37-1 SRS₁₄-41 
• 17700-55-9 N-(2,6-Dichloro-3-methylphenyl)acetamide 

Downstream Products

• 1360622-16-7 N-(3-cyano-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide 
• 1360622-17-8 N-(2,4-dichloro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide 

Relevant articles and documents

NEW COMPOUNDS

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R6, R7, R8 have meanings given in the description.

NEW COMPOUNDS

This invention relates to compounds of formula (I) their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R6, R7, R8 have meanings given in the description.