124236-29-9Relevant articles and documents
Trans N-ethyl-N-(2 the [...] -alkyl-phenyl) - 2-butenamide synthetic method
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Paragraph 0024; 0026; 0027, (2016/10/07)
The invention relates to a synthesis method for trans N-ethyl-N-(2'-alkyl phenyl)-2-butenamide. The method comprises the steps of: 1) adding trans 2- butenoic acid into a reaction bottle, conducting dilution with an alkane solvent, performing cooling to 0-10DEG C, adding thionyl chloride dropwise, and then carrying out reaction at 10-50DEG C for 3-4h for standby use; 2) adding N-ethyl-2-alkyl aniline into the reaction bottle, conducting dilution with an alkane solvent, adding an alkaline aqueous solution, subjecting the mixed solution to stirring reaction at room temperature, adding the mixed solution obtained in step 1) slowly in a dropwise manner, and then carrying out reaction at 60-90DEG C for 5-6h at the end of dropwise adding; and 3) at the end of the reaction, separating out the organic phase, and washing the organic phase to neutral by water, conducting room temperature distillation to remove the solvent, and then performing pressure reduced distillation to separate the product. The method is simple, has high product yield, and can produce the high purity trans-structure product.
