124236-61-9 Usage
Uses
Used in Pharmaceutical Research and Development:
3-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N-(1-methylpropyl)is used as a chemical compound in the research and development of pharmaceutical drugs. Its potential as a ligand for various receptors or enzymes and possible biological activity make it a valuable asset in the discovery and design of new therapeutic agents.
Used in Drug Discovery:
In the field of drug discovery, 3-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N-(1-methylpropyl)is utilized as a starting material or intermediate in the synthesis of novel drug candidates. Its unique structure and potential interactions with biological targets can lead to the development of new medications with improved efficacy and safety profiles.
Used in Medicinal Chemistry:
3-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N-(1-methylpropyl)is employed in medicinal chemistry as a building block for the design and optimization of drug molecules. Its chemical properties and structural features can be modified to enhance its binding affinity, selectivity, and pharmacokinetic properties, ultimately contributing to the development of more effective therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 124236-61-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,2,3 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 124236-61:
(8*1)+(7*2)+(6*4)+(5*2)+(4*3)+(3*6)+(2*6)+(1*1)=99
99 % 10 = 9
So 124236-61-9 is a valid CAS Registry Number.
124236-61-9Relevant academic research and scientific papers
A novel approach for the synthesis of the peripheral benzodiazepine receptor ligand, PK11195
Stevenson, Louise,Pimlott, Sally L.,Sutherland, Andrew
, p. 7137 - 7139 (2008/03/11)
A new synthesis of the peripheral benzodiazepine receptor ligand, PK11195 has been developed in only six-steps using a Heck-type reaction and a Suzuki coupling to effect the key transformations. The flexibility of this new approach is demonstrated by the
1-(Phenyl)isoquinoline carboxamides: A novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors
Jiang, Jian-Kang,Thomas, Craig J.,Neumann, Susanne,Lu, Xinping,Rice, Kenner C.,Gershengorn, Marvin C.
, p. 733 - 736 (2007/10/03)
We report the synthesis of and binding to the two subtypes of mouse thyrotropin-releasing hormone (TRH) receptors, TRH-R1 and TRH-R2, of several 1-(phenyl)isoquinoline carboxamide analogues. These analogues showed a degree of selectivity for binding at TR
Novel irreversible ligands specific for 'peripheral' type benzodiazepine receptors: (±)-, (+)-, and (-)-1-(2-chlorophenyl)-N-(1 methylpropyl)-N-(2-isothiocyanatoethyl)-3-isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlor
Newman,Lueddens,Skolnick,Rice
, p. 1901 - 1905 (2007/10/02)
Novel ligands that bind irreversibly and selectively to 'peripheral' type benzodiazepine receptors (PBR) have been prepared. These compounds inhibits radiolabeled binding to PBR in the nanomolar range. The 2-isothiocyanatoethyl analogue of Ro 5-4864 (1-me
