439614-60-5

Basic information

• Product Name: 3-Isoquinolinecarboxaldehyde, 1-(2-chlorophenyl)-
• CAS NO: 439614-60-5
• Molecular Formula: C16H10ClNO
• Molecular Weight: 267.714
• Mol File: 439614-60-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-Isoquinolinecarboxaldehyde, 1-(2-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Isoquinolinecarboxaldehyde, 1-(2-chlorophenyl)-(439614-60-5)
• EPA Substance Registry System: 3-Isoquinolinecarboxaldehyde, 1-(2-chlorophenyl)-(439614-60-5)

Safety Data

• Hazardous Substances Data: 439614-60-5(Hazardous Substances Data)

Upstream product

• 92853-34-4 1-(2-chlorophenyl)-3-methylisoquinoline 
• 609-65-4 o-chlorobenzoyl chloride 
• 419535-34-5 2-chloro-N-(2-hydroxy-1-methyl-2-phenylethyl)benzamide 
• 92874-45-8 1-(2-chlorophenyl)-3-methyl-3,4-dihydroisoquinoline 
• 76005-94-2 2-chlorophenyl(phenyl)methanimine 
• 60-15-1 2-amino-1-phenylpropane 
• 93010-73-2 N-(β-phenyl)isopropyl-o-chlorobenzamide 
• 53631-70-2 d,l-norephedrine hydrochloride 
• 501084-68-0 1-(2-chloro-phenyl)-3-dibromomethyl-isoquinoline 

Downstream Products

• 109960-06-7 1-(2-chlorophenyl)-3-isoquinolinecarboxylic acid chloride 
• 124236-61-9 (+/-)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide 
• 89242-09-1 1-(2-chlorophenyl)-3-isoquinolinecarboxylic acid 

Relevant articles and documents

Redox-Neutral Manganese(I)-Catalyzed C?H Activation: Traceless Directing Group Enabled Regioselective Annulation

A strategy is reported in which traceless directing groups (TDGs) are used to promote the redox-neutral MnI-catalyzed regioselective synthesis of N-heterocycles. Alkyne coupling partners bearing a traceless directing group, which serves as both the chelator and internal oxidant, were used to control the regioselectivity of the annulation reactions. This operationally simple approach is highly effective with previously challenging unsymmetrical alkyne systems, including unbiased dialkyl alkynes, with perfect regioselectivity. The simple conditions and the ability to carry out synthesis on a gram scale underscore the usefulness of this method. The application of this strategy in the concise synthesis of the bioactive compound PK11209 and the pharmaceutical moxaverine is also described.

Multi-use multimodal imaging chelates

Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10 tetraazacyclododecane (“cyclen”) having varying chelating ions, phosphoester chains, and light harvesting moieties. By changing the chelating ion, phosphoester chain length and/or the light harvesting moiety different imaging techniques, such as MRI, CT, fluorescence and absorption, x-ray and NIR, may be employed to image the tissue cells. Additionally, the cyclen-based chelates may be conjugated to provide for site-specific delivery of the cyclen-based chelate to the desired tissue cells. The cyclen-based chelates may also be delivered to the tissue cells by attaching the cyclen-based chelates to a polymeric delivery vehicle. Although these cyclen-based chelates have a wide variety of application, the preferred use is for imaging of cancer cells, such as brain cancer, for improving resection of a cancerous tissue.

Facile, Efficient Conjugation of a Trifunctional Lanthanide Chelate to a Peripheral Benzodiazepine Receptor Ligand

matrix presented Receptor-mediated imaging and therapy of diseased tissue is rapidly gaining favor in the medical community. The synthesis and facile aqueous/ organic coupling of a peripheral-type benzodiazepine receptor ligand to a cyclen-based fluoropho