1242450-40-3

Upstream product

• 695183-22-3 9-((2R,3R,4S,5R)-3-azido-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-9H-purin-6-amine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1242450-41-4 N-(9-((2R,3R,4S,5R)-3-azido-4-(tert-butyldimethylsilyloxy)-5(hydroxymethyl) tetrahydro-furan-2-yl)-9H-purin-6-yl)benzamide 

Relevant academic research and scientific papers

The synthesis of diverse adenosine 5'-phosphonate analogues as chain terminators against hepatitis C virus (HCV)

Adenosine 5'-phosphonates have been reported as potential chain terminators against Hepatitis C virus (HCV); therefore, we developed convenient sequences for synthesis of modified adenosine 5'-phosphonates in which the hydroxyl group at 2' or 3'-position of the sugar moiety is substituted with the azido or amino group and the oxymethyl group at the 4'-position is modified by the ethylene or vinyl group. This synthetic sequence can provide six adenosine 5'-phosphonates via one protocol, and is considered to be very efficient and a convenient route of synthesis. An assay of adenosine 5'-phosphonate analogues (1, 2, 3, 4, 5, and 6) against HCV infection is now in progress.