1242450-41-4

Upstream product

• 1242450-40-3 N-(9-((2R,3R,4S,5R)-3-azido-4-(tert-butyldimethylsilyloxy)-5-((tert-butyldimethyl silyloxy)methyl)-tetrahydrofuran-2-yl)-9H-purin-6-yl)-N-benzoylbenzamide 
• 1245200-31-0 6-N-benzoyl-2′-azido-3′,5′-bis-O-(tert-butyldimethylsilyl)-2′-deoxyadenosine 

Downstream Products

• 1242450-42-5 diphenyl (E)-2-((2R,3S,4R,5R)-4-azido-5-(6-benzamido-9H-purin-9-yl)-3-(tert-butyldime-thylsilyloxy)-tetrahydrofuran-2-yl)vinylphosphonate 
• 1422956-11-3 (2R,3S,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl((2R,3S,4R,5R)-4-azido-5-(6-benzamido-9H-purin-9-yl)-3-(tert-butyldimethylsilyloxy)tetrahydrofuran-2-yl)methyl 2-cyanoethyl phosphate 

Relevant academic research and scientific papers

Decoding the logic of the tRNA regiospecificity of nonribosomal femX Wv aminoacyl transferase www.angewandte.org

Natural selection: Replacement of the 3′-OH group of Ala-tRNA Ala with 3′-H affected FemXWv-catalyzed aminoacyl transfer from the 2 -position, but not substrate binding. The ability of FemXWv to bind and transacylate the 3′-O-Ala isomer initially formed by alanyl-tRNA synthetase (AlaRS) may be crucial for efficient competition with the ribosome (see scheme). (Figure Presented).

The synthesis of diverse adenosine 5'-phosphonate analogues as chain terminators against hepatitis C virus (HCV)

Adenosine 5'-phosphonates have been reported as potential chain terminators against Hepatitis C virus (HCV); therefore, we developed convenient sequences for synthesis of modified adenosine 5'-phosphonates in which the hydroxyl group at 2' or 3'-position of the sugar moiety is substituted with the azido or amino group and the oxymethyl group at the 4'-position is modified by the ethylene or vinyl group. This synthetic sequence can provide six adenosine 5'-phosphonates via one protocol, and is considered to be very efficient and a convenient route of synthesis. An assay of adenosine 5'-phosphonate analogues (1, 2, 3, 4, 5, and 6) against HCV infection is now in progress.