1242516-41-1

Upstream product

• 1242516-24-0 (3R,4S)-ethyl 1-(4-nitrophenylsulfonyl)-2-oxo-4-phenylpyrrolidine-3-carboxylate 
• 71639-13-9 diethyl 2-(3-nitrophenylethyl)malonate 
• 75-52-5 nitromethane 
• 100-52-7 benzaldehyde 
• 105-53-3 diethyl malonate 

Downstream Products

• 1486546-27-3 C₁₃H₁₇NO₂ 

Relevant academic research and scientific papers

METHOD OF PREPARING PHARMACEUTICAL BY CONTINUOUS FLOW MULTI-STAGE REACTION

PROBLEM TO BE SOLVED: To obtain optic active compounds efficiently by incorporating, into a multi-stage flow synthesis system, a column provided with a solid-phase synthesis device necessary for synthesizing optic active compounds to become pharmaceutical

Organocatalytic enantioselective conjugate addition of nitromethane to alkylidenemalonates: Asymmetric synthesis of pyrrolidine-3-carboxylic acid derivatives

A highly enantioselective nitromethane addition to alkylidene malonates catalyzed by cinchona-alkaloid derived thiourea based organocatalyst has been developed that offers a new route to the synthesis of substituted pyrrolidine-3-carboxylic acid derivatives and 3-arylpyrrolidines/pyrrolidones. The Royal Society of Chemistry 2013.

Lewis acid catalyzed highly stereoselective domino-ring-opening cyclization of activated aziridines with enolates: Synthesis of functionalized chiral γ-lactams

Figure presented. A highly enantio- and diastereoselective Lewis acid catalyzed SN2-type ring opening followed by cyclization of aziridines with active methylene carbon nucleophiles to functionalized chiral γ-lactams in a domino fashion has been developed. γ-Lactams have been desulfonated and decarboxylated, providing pyrrolidone-3-carboxylate and N-tosylpyrrolidinone derivatives, respectively, in good yields.