1242555-27-6

Basic information

• Product Name: 1-(2-amino-4,5-difluorophenyl)ethanone
• Synonyms: 1-(2-amino-4,5-difluorophenyl)ethanone
• CAS NO: 1242555-27-6
• Molecular Weight: 171.146
• Mol File: 1242555-27-6.mol

Chemical Properties

• CAS DataBase Reference: 1-(2-amino-4,5-difluorophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-amino-4,5-difluorophenyl)ethanone(1242555-27-6)
• EPA Substance Registry System: 1-(2-amino-4,5-difluorophenyl)ethanone(1242555-27-6)

Safety Data

• Hazardous Substances Data: 1242555-27-6(Hazardous Substances Data)

Usage

Uses

Used in Recreational Drug Industry:
1-(2-amino-4,5-difluorophenyl)ethanone is used as a recreational drug for its stimulant and psychoactive effects, which include increased alertness, energy, and euphoria. However, it is important to note that the compound has a high potential for abuse and addiction, and its use can lead to negative side effects such as insomnia, anxiety, and increased heart rate.

Upstream product

• 64695-79-0 2-bromo-4,5-difluoro-aniline 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 67-56-1 methanol 
• 1034269-64-1 4,5-difluoro-2-[2-(trimethylsilyl)ethynyl]aniline 
• 132123-54-7 3,4,5-trifluorobenzaldehyde 
• 847685-01-2 2-iodo-4,5-difluoroaniline 
• 3863-11-4 3,4-difluoroaniline 
• 83506-93-8 2-amino-4,5-difluorobenzoic acid 
• 917-54-4 methyllithium 

Downstream Products

• 1429231-11-7 N-(2-acetyl-4,5-difluorophenyl)-3-(5H-imidazo[2,1-a]isoindol-2-yl)propionamide 

Relevant articles and documents

p-Toluenesulfonic acid mediated one-pot cascade synthesis and cytotoxicity evaluation of polyfluorinated 2-aryl-2,3-dihydroquinolin-4-ones and their derivatives

Biologically interesting polyfluorinated 2-aryl-2,3-dihydroquinolin-4-ones (5), 3-benzylidene-2-aryl-2,3-dihydroquinolin-4-ones (6) and 7-methyl-6-aryl-5,6-dihydrodibenzo[b,h][1,6] naphthyridines (7) were synthesized using a mild and efficient one-pot procedure starting from 2-aminoacetophenones and trifluorobenzaldehyde in the presence of p-toluenesulfonic acid. Thanks to the use of a high-active polyfluorinated electrophile this synthetic protocol provides rapid access to a variety of bioactive heterocyclic assemblies. Screening of the synthesized compounds for their cytotoxic activity against human tumor cell lines, including breast cancer (MCF-7), lung carcinoma (A-549), and myeloma cancer cells (RPMI 8226) revealed that polyfluorinated compounds 6b–f showed manifest cytotoxic effects (with IC50 = 2.5 ÷ 7 μM for MCF-7 and RPMI 8226 cancer cells).

ERBB/BTK INHIBITORS

Disclosed are compounds inhibiting ErbBs (e. g., EGFR or Her 2), especially mutant forms of ErbBs, and BTK, pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compou

P -Toluenesulfonic Acid Induced Conversion of Fluorinated Trimethylsilylethynylanilines into Aminoacetophenones: Versatile Precursors for the Synthesis of Benzoazaheterocycles

A simple and efficient approach to the synthesis of fluorinated amino-substituted acetophenones in good to excellent yields is reported. The heart of the proposed method consists of conversion of a Me 3 Si-C≡C- moiety into a MeC(=O)- group in the presence of p -tolu ene sulfonic acid (p -TSA) passing a stage of ethynylaniline formation. The reaction is metal-free, proceeds under mild conditions, and uses readily available starting compounds (trimethylsilylarylacetylene derivatives). The reaction provides access to amino-substituted acetophenones, which may serve as precursors for the synthesis of polyfluorinated azaheterocycles, having potential anticarcinogenic activity.

Br?nsted acid/rhodium(II) cooperative catalytic asymmetric three-component aldol-type reaction for the synthesis of 3-amino oxindoles

Cooperation is key! Chiral Br?nsted acid/rhodium(II) cooperative catalysis enabled an enantioselective three-component aldol-type reaction of 3-diazo oxindoles and anilines with glyoxylates to give highly functionalized and structurally diverse 3-amino oxindoles in high stereoselectivity (>20:1 d.r., 99 % ee; see scheme). Copyright